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Seven cases illustrating difficulties in the treatment of MPO-ANCA-positive refractory otitis media
https://fmu.repo.nii.ac.jp/records/2002108
https://fmu.repo.nii.ac.jp/records/20021087313cf16-7321-4bf3-9ca7-1d71ca68a585
| 名前 / ファイル | ライセンス | アクション |
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FksmJMedSci_70_p175.pdf (1.0 MB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2024-12-04 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Seven cases illustrating difficulties in the treatment of MPO-ANCA-positive refractory otitis media | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
Otsuki, Koshi
× Otsuki, Koshi
× Imaizumi, Mitsuyoshi
× Murono, Shigeyuki
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| 権利情報 | ||||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |||||||||||
| 権利情報 | © 2024 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | There are increasing reports of patients with refractory otitis media caused by anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), especially myeloperoxidase (MPO)-ANCA-positive middle ear disease. However, making a definitive diagnosis can be difficult, which can adversely affect the outcome of treatment. We reviewed the diagnostic features of MPO-ANCA-positive middle ear disease and here discuss the difficulties of timely diagnosis and treatment. Seven cases were eligible (6 women, 1 man;aged 57-83 years), and all were MPO-ANCA positive and proteinase 3 (PR3)-ANCA negative. The patients were referred to our institution for management of intractable otitis media (2/7), progressive hearing loss (7/7) with facial palsy (1/7), and/or a high MPO-ANCA titer (5/7). All patients underwent tapering steroid therapy and their MPO-ANCA titer was monitored. Refractory MPO-ANCA-positive otitis media was noted:5 of 7 cases showed improvement with tapering steroid therapy but cure was not achieved in the remaining 2 cases. This study demonstrates the difficulties in the diagnosis and treatment of localized AAV. Early diagnosis and treatment can improve the prognosis of patients with AAV but global diagnostic criteria for ear disease have not been established. Additional cases should be prospectively examined to establish a treatment for MPO-ANCA-positive middle ear disease. | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 書誌情報 |
en : Fukushima journal of medical science 巻 70, 号 4, p. 175-182, 発行日 2024 |
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| 関連情報 | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.2023-21 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 39370277 | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA0065246X | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | myeloperoxidase (MPO)-ANCA | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | proteinase 3 (PR3)-ANCA | |||||||||||
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| 主題Scheme | MeSH | |||||||||||
| 主題 | Humans | |||||||||||
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| 主題Scheme | MeSH | |||||||||||
| 主題 | Female | |||||||||||
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| 主題Scheme | MeSH | |||||||||||
| 主題 | Male | |||||||||||
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| 主題Scheme | MeSH | |||||||||||
| 主題 | Middle Aged | |||||||||||
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| 主題Scheme | MeSH | |||||||||||
| 主題 | Aged | |||||||||||
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| 主題Scheme | MeSH | |||||||||||
| 主題 | Otitis Media | |||||||||||
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| 主題Scheme | MeSH | |||||||||||
| 主題 | Peroxidase | |||||||||||
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| 主題Scheme | MeSH | |||||||||||
| 主題 | Aged, 80 and over | |||||||||||
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| 主題Scheme | MeSH | |||||||||||
| 主題 | Antibodies, Antineutrophil Cytoplasmic | |||||||||||
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| 主題Scheme | MeSH | |||||||||||
| 主題 | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | |||||||||||
