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  1. 福島医学会
  2. Fukushima Journal of Medical Science
  3. Vol.64 (2018)

Prognostic impact of preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer with special reference to myeloid-derived suppressor cells

https://fmu.repo.nii.ac.jp/records/2001957
https://fmu.repo.nii.ac.jp/records/2001957
7c4b12a0-f91f-41b9-bb28-528fc4a10851
名前 / ファイル ライセンス アクション
FksmJMedSci_64_p64.pdf FksmJMedSci_64_p64.pdf (2.8 MB)
Item type デフォルトアイテムタイプ(フル)fmu(1)
公開日 2018-09-14
タイトル
タイトル Prognostic impact of preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer with special reference to myeloid-derived suppressor cells
言語 en
作成者 Shimura, Tatsuo

× Shimura, Tatsuo

en Shimura, Tatsuo

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Shibata, Masahiko

× Shibata, Masahiko

en Shibata, Masahiko

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Gonda, Kenji

× Gonda, Kenji

en Gonda, Kenji

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Hayase, Suguru

× Hayase, Suguru

en Hayase, Suguru

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Sakamoto, Wataru

× Sakamoto, Wataru

en Sakamoto, Wataru

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Okayama, Hirokazu

× Okayama, Hirokazu

en Okayama, Hirokazu

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Fujita, Shotaro

× Fujita, Shotaro

en Fujita, Shotaro

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Saito, Motonobu

× Saito, Motonobu

en Saito, Motonobu

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Momma, Tomoyuki

× Momma, Tomoyuki

en Momma, Tomoyuki

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Ohki, Shinji

× Ohki, Shinji

en Ohki, Shinji

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Kono, Koji

× Kono, Koji

en Kono, Koji

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権利情報
権利情報 © 2018 The Fukushima Society of Medical Science
内容記述
内容記述タイプ Abstract
内容記述 Aims: We aimed to investigate the relationship of colorectal cancer prognosis and inflammatory parameters, including neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR), with reference to circulating myeloid-derived suppressor cells (MDSCs) in the current study. Patients and Methods: Thirty-five patients who underwent curative-intent surgery were enrolled. A receiver-operating characteristic curve (ROC) was used to assess the usefulness of candidates for prognostic factors. Recurrence-free survival (RFS) was calculated using the Kaplan-Meier method, and the candidates for prognostic factors were assessed by a Cox proportional hazard model. Results: ROC curve analyses determined cutoff values for NLR and LMR as 2.9 and 2.4, respectively. The percentage of MDSCs in patients with LMR ≤ 2.4 was statistically higher than in those with LMR > 2.4 (p = 0.012). The patients with LMR ≤ 2.4 exhibited a statistically lower RFS than those with LMR > 2.4 (p = 0.008). These results were also observed in patients with stage II + III disease. LMR was an independent prognostic factor of RFS in colorectal cancer patients (hazard ratio: 7.757, 95% confidence interval: 1.462-41.152, p = 0.016). Conclusion: Lower LMR was associated with poor prognosis in colorectal cancer patients; whereas, higher circulating MDSCs were observed in patients with lower LMR.
出版者
出版者 The Fukushima Society of Medical Science
言語
言語 eng
書誌情報 en : Fukushima Journal of Medical Science

巻 64, 号 2, p. 64-72, 発行日 2018
関連情報
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.5387/fms.2018-10
関連情報
識別子タイプ PMID
関連識別子 30012939
関連情報
識別子タイプ ICHUSHI
関連識別子 2020139714
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0016-2590
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 2185-4610
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA0065246X
主題
主題Scheme Other
主題 colorectal cancer
主題
主題Scheme Other
主題 lymphocyte-to-monocyte ratio
主題
主題Scheme Other
主題 myeloid-derived suppressor cells
主題
主題Scheme Other
主題 neutrophil-to-lymphocyte-ratio
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