{"created":"2024-12-02T04:08:09.829479+00:00","id":2001957,"links":{},"metadata":{"_buckets":{"deposit":"127aa078-f6e3-4fc1-8f3d-4c447401243a"},"_deposit":{"created_by":8,"id":"2001957","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2001957"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02001957","sets":["1732778801467:1732778962699:1733108131262"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Prognostic impact of preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer with special reference to myeloid-derived suppressor cells","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimura, Tatsuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shibata, Masahiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Gonda, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hayase, Suguru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sakamoto, Wataru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okayama, Hirokazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fujita, Shotaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Saito, Motonobu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Momma, Tomoyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohki, Shinji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kono, Koji","creatorNameLang":"en"}]}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2018 The Fukushima Society of Medical Science","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"colorectal cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lymphocyte-to-monocyte ratio","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"myeloid-derived suppressor cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neutrophil-to-lymphocyte-ratio","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Aims: We aimed to investigate the relationship of colorectal cancer prognosis and inflammatory parameters, including neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR), with reference to circulating myeloid-derived suppressor cells (MDSCs) in the current study. Patients and Methods: Thirty-five patients who underwent curative-intent surgery were enrolled. A receiver-operating characteristic curve (ROC) was used to assess the usefulness of candidates for prognostic factors. Recurrence-free survival (RFS) was calculated using the Kaplan-Meier method, and the candidates for prognostic factors were assessed by a Cox proportional hazard model. Results: ROC curve analyses determined cutoff values for NLR and LMR as 2.9 and 2.4, respectively. The percentage of MDSCs in patients with LMR ≤ 2.4 was statistically higher than in those with LMR > 2.4 (p = 0.012). The patients with LMR ≤ 2.4 exhibited a statistically lower RFS than those with LMR > 2.4 (p = 0.008). These results were also observed in patients with stage II + III disease. LMR was an independent prognostic factor of RFS in colorectal cancer patients (hazard ratio: 7.757, 95% confidence interval: 1.462-41.152, p = 0.016). Conclusion: Lower LMR was associated with poor prognosis in colorectal cancer patients; whereas, higher circulating MDSCs were observed in patients with lower LMR.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"The Fukushima Society of Medical Science","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0016-2590","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2185-4610","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA0065246X","subitem_source_identifier_type":"NCID"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"72","bibliographicPageStart":"64","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"Fukushima Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5387/fms.2018-10","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"30012939","subitem_relation_type_select":"PMID"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2020139714","subitem_relation_type_select":"ICHUSHI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-09-14"}],"displaytype":"detail","filename":"FksmJMedSci_64_p64.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2001957/files/FksmJMedSci_64_p64.pdf"},"version_id":"27566c73-201e-460e-8b9d-a0c9e39e2df6"}]},"item_title":"Prognostic impact of preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer with special reference to myeloid-derived suppressor cells","item_type_id":"40002","owner":"8","path":["1733108131262"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-09-14"},"publish_date":"2018-09-14","publish_status":"0","recid":"2001957","relation_version_is_last":true,"title":["Prognostic impact of preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer with special reference to myeloid-derived suppressor cells"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2024-12-02T04:12:31.228242+00:00"}