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Inhibitory effect of β-hydroxybutyric acid on L-type Ca^{2+} current under β-adrenergic stimulation in guinea pig Cardiac ventricular myocytes
https://fmu.repo.nii.ac.jp/records/2001829
https://fmu.repo.nii.ac.jp/records/2001829d72df752-40d0-4d31-be6c-1d1159b12047
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FksmJMedSci_58_p144.pdf (391.2 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||
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| 公開日 | 2012-12-25 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Inhibitory effect of β-hydroxybutyric acid on L-type Ca^{2+} current under β-adrenergic stimulation in guinea pig Cardiac ventricular myocytes | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
Kurihara, Masato
× Kurihara, Masato
× Akama, Youichi
× Kimura, Junko
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| 権利情報 | ||||||||||||
| 権利情報 | © 2012 The Fukushima Society of Medical Science | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Severe ketoacidosis induces heart failure and cardiac arrest, but its mechanism is unknown. Recently, hydroxy-carboxylic acid receptor 2 (HCA(2)) was found to be a receptor for a ketone body, β-hydroxybutyric acid (BHB), and is coupled with Gi-GTP binding protein. HCA(2) expression was reported in the guinea pig heart. Therefore, using guinea pig cardiac myocytes, we investigated effects of BHB on L-type Ca(2+) current pre-augmented with β-adrenoceptor agonist, isoproterenol under the whole-cell voltage clamp. BHB significantly reduced the Ca(2+) current pre-augmented with isoproterenol. The effect of BHB was concentration dependent with IC(50) of 1.1 mM. Nicotinic acid (NA), another ligand for HCA(2), also exerted an effect on the Ca(2+) current similar to that of BHB. The effects of BHB and NA were reduced by a specific Gi inhibitor, pertussis toxin in the pipette solution. Our results suggest that BHB activates Gi-coupled signal transduction pathway via HCA(2) in guinea pig cardiac myocytes. The HCA(2)-mediated signal transduction may be associated with ketoacidosis-induced cardiac suppression. | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 58, 号 2, p. 144-150, 発行日 2012 |
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| 関連情報 | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.58.144 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 23237870 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | ICHUSHI | |||||||||||
| 関連識別子 | 2013249055 | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA0065246X | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | β-hydroxybutyric acid | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | ketone body | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | L-type Ca2+ current | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | cardiac myocyte | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | HCA2 receptor | |||||||||||
