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Association of the toll-like receptor 9 gene polymorphisms with behcet's disease in a Japanese population
https://fmu.repo.nii.ac.jp/records/2001827
https://fmu.repo.nii.ac.jp/records/20018276aef0a98-810a-4a5e-8820-3bb476bf6d0a
| 名前 / ファイル | ライセンス | アクション |
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FksmJMedSci_58_p127.pdf (256.7 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||||||
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| 公開日 | 2012-12-25 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Association of the toll-like receptor 9 gene polymorphisms with behcet's disease in a Japanese population | |||||||||||||||
| 言語 | en | |||||||||||||||
| 作成者 |
Sakamoto, Natsumi
× Sakamoto, Natsumi
× Sekine, Hideharu
× Kobayashi, Hiroko
× Sato, Yukio
× Ohira, Hiromasa
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| 権利情報 | ||||||||||||||||
| 権利情報 | © 2012 The Fukushima Society of Medical Science | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Bacterial infection (i.e., Streptococcus sanguinis) has been suggested to be related to pathogenesis and/or symptom of Behcet's disease (BD). Toll-like receptor 9 (TLR9) plays an important role in both the innate and adaptive immune systems by recognizing a component of bacterial DNA (i.e., CpG-DNA). Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) in TLR9 were associated with infectious and autoimmune/autoinflammatory diseases. In this study, we detected five SNPs with BD patients in a Japanese population. Allele frequency analysis of the three common SNPs (-1486: T/C (promoter region), 1174: A/G (intron 1), 2848: G/A (exon 2; Pro545Pro)) showed no statistically significant difference between the BD patients and the healthy controls. However, genotyping analysis revealed that the homozygous genotypes -1486CC and 1174GG were significantly more frequent in the BD patients compared to the healthy controls (P=0.048 and P=0.027, respectively). The homozygous diplotype distribution C-G-A/C-G-A was significantly more frequent in the BD patients compared to the healthy controls (P=0.041). For reporter gene assay, the plasmid construct carrying diplotype distribution C-G/C-G of the -1486T/C and 1174A/G SNPs showed significantly higher luciferase activity compared to the plasmid construct carrying diplotype distribution T-A/T-A (P=0.019). These results suggested an association of the homozygous genotypes and homozygous diplotype configuration of the TLR9 SNPs with susceptibility to BD in the Japanese population. | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 58, 号 2, p. 127-135, 発行日 2012 |
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| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.58.127 | |||||||||||||||
| 関連情報 | ||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||
| 関連識別子 | 23237868 | |||||||||||||||
| 関連情報 | ||||||||||||||||
| 識別子タイプ | ICHUSHI | |||||||||||||||
| 関連識別子 | 2013249053 | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA0065246X | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Toll-like receptor 9 | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Behcet's disease | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Single nucleotide polymorphism | |||||||||||||||
