| アイテムタイプ |
デフォルトアイテムタイプ（フル）fmu(1) |
| 公開日 |
2012-12-25 |
| タイトル |
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|
タイトル |
Association of the toll-like receptor 9 gene polymorphisms with behcet's disease in a Japanese population |
|
言語 |
en |
| 作成者 |
Sakamoto, Natsumi
Sekine, Hideharu
Kobayashi, Hiroko
Sato, Yukio
Ohira, Hiromasa
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| 権利情報 |
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|
権利情報 |
© 2012 The Fukushima Society of Medical Science |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Bacterial infection (i.e., Streptococcus sanguinis) has been suggested to be related to pathogenesis and/or symptom of Behcet's disease (BD). Toll-like receptor 9 (TLR9) plays an important role in both the innate and adaptive immune systems by recognizing a component of bacterial DNA (i.e., CpG-DNA). Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) in TLR9 were associated with infectious and autoimmune/autoinflammatory diseases. In this study, we detected five SNPs with BD patients in a Japanese population. Allele frequency analysis of the three common SNPs (-1486: T/C (promoter region), 1174: A/G (intron 1), 2848: G/A (exon 2; Pro545Pro)) showed no statistically significant difference between the BD patients and the healthy controls. However, genotyping analysis revealed that the homozygous genotypes -1486CC and 1174GG were significantly more frequent in the BD patients compared to the healthy controls (P=0.048 and P=0.027, respectively). The homozygous diplotype distribution C-G-A/C-G-A was significantly more frequent in the BD patients compared to the healthy controls (P=0.041). For reporter gene assay, the plasmid construct carrying diplotype distribution C-G/C-G of the -1486T/C and 1174A/G SNPs showed significantly higher luciferase activity compared to the plasmid construct carrying diplotype distribution T-A/T-A (P=0.019). These results suggested an association of the homozygous genotypes and homozygous diplotype configuration of the TLR9 SNPs with susceptibility to BD in the Japanese population. |
| 出版者 |
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出版者 |
The Fukushima Society of Medical Science |
| 言語 |
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|
言語 |
eng |
| 書誌情報 |
en : Fukushima Journal of Medical Science
巻 58,
号 2,
p. 127-135,
発行日 2012
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| 関連情報 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.5387/fms.58.127 |
| 関連情報 |
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識別子タイプ |
PMID |
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関連識別子 |
23237868 |
| 関連情報 |
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識別子タイプ |
ICHUSHI |
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関連識別子 |
2013249053 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0016-2590 |
| 収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2185-4610 |
| 収録物識別子 |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA0065246X |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
Toll-like receptor 9 |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
Behcet's disease |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
Single nucleotide polymorphism |
FksmJMedSci_58_p127.pdf (256.7 KB)
