{"created":"2024-11-29T09:27:26.582073+00:00","id":2001827,"links":{},"metadata":{"_buckets":{"deposit":"7ae06478-5c6b-4dd0-bc03-d80309a8b776"},"_deposit":{"created_by":8,"id":"2001827","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2001827"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02001827","sets":["1732778801467:1732778962699:1732871851743"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Association of the toll-like receptor 9 gene polymorphisms with behcet's disease in a Japanese population","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakamoto, Natsumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sekine, Hideharu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kobayashi, Hiroko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sato, Yukio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohira, Hiromasa","creatorNameLang":"en"}]}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2012 The Fukushima Society of Medical Science","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Toll-like receptor 9","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Behcet's disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Single nucleotide polymorphism","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Bacterial infection (i.e., Streptococcus sanguinis) has been suggested to be related to pathogenesis and/or symptom of Behcet's disease (BD). Toll-like receptor 9 (TLR9) plays an important role in both the innate and adaptive immune systems by recognizing a component of bacterial DNA (i.e., CpG-DNA). Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) in TLR9 were associated with infectious and autoimmune/autoinflammatory diseases. In this study, we detected five SNPs with BD patients in a Japanese population. Allele frequency analysis of the three common SNPs (-1486: T/C (promoter region), 1174: A/G (intron 1), 2848: G/A (exon 2; Pro545Pro)) showed no statistically significant difference between the BD patients and the healthy controls. However, genotyping analysis revealed that the homozygous genotypes -1486CC and 1174GG were significantly more frequent in the BD patients compared to the healthy controls (P=0.048 and P=0.027, respectively). The homozygous diplotype distribution C-G-A/C-G-A was significantly more frequent in the BD patients compared to the healthy controls (P=0.041). For reporter gene assay, the plasmid construct carrying diplotype distribution C-G/C-G of the -1486T/C and 1174A/G SNPs showed significantly higher luciferase activity compared to the plasmid construct carrying diplotype distribution T-A/T-A (P=0.019). These results suggested an association of the homozygous genotypes and homozygous diplotype configuration of the TLR9 SNPs with susceptibility to BD in the Japanese population.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"The Fukushima Society of Medical Science","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0016-2590","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2185-4610","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA0065246X","subitem_source_identifier_type":"NCID"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"135","bibliographicPageStart":"127","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"Fukushima Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5387/fms.58.127","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"23237868","subitem_relation_type_select":"PMID"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2013249053","subitem_relation_type_select":"ICHUSHI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2012-12-25"}],"displaytype":"detail","filename":"FksmJMedSci_58_p127.pdf","filesize":[{"value":"256.7 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2001827/files/FksmJMedSci_58_p127.pdf"},"version_id":"0ea2106c-47f2-4061-8396-de34c766d628"}]},"item_title":"Association of the toll-like receptor 9 gene polymorphisms with behcet's disease in a Japanese population","item_type_id":"40002","owner":"8","path":["1732871851743"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-12-25"},"publish_date":"2012-12-25","publish_status":"0","recid":"2001827","relation_version_is_last":true,"title":["Association of the toll-like receptor 9 gene polymorphisms with behcet's disease in a Japanese population"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2025-01-09T09:03:55.077788+00:00"}