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The endocrinological responses of veno-venous extracorporeal membrane oxygenation on hypoxic fetal lambs
https://fmu.repo.nii.ac.jp/records/2001810
https://fmu.repo.nii.ac.jp/records/20018101dcd3016-f4c9-4658-8f97-b34098840c3a
| 名前 / ファイル | ライセンス | アクション |
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FksmJMedSci_58_p9.pdf (434.4 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||||||||
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| 公開日 | 2012-08-01 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | The endocrinological responses of veno-venous extracorporeal membrane oxygenation on hypoxic fetal lambs | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 作成者 |
Nomura, Yasuhisa
× Nomura, Yasuhisa
× Kato, Katsuhiko
× Fujimori, Keiya
× Shiroto, Tomohiro
× Ishida, Tomohiko
× Sato, Akira
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| 権利情報 | ||||||||||||||||||
| 権利情報 | © 2012 The Fukushima Society of Medical Science | |||||||||||||||||
| 内容記述 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Objective: The purpose of this study was to observe endocrinological responses of veno-arterial and veno-venous extracorporeal membrane oxygenation (V-A and V-V ECMO) to support fetal oxygenation in utero. Methods: An ECMO system with a centrifugal pump was applied to six chronically instrumented fetal lambs, at 126-134 days of gestation. Blood was obtained through a double-lumen catheter inserted into the right atrium. After oxygenation, the blood was returned through a single-lumen catheter into either the carotid artery (veno-arterial; V-A ECMO) or the right atrium (V-V ECMO). After fetal hypoxia had been experimentally produced, V-A ECMO or V-V ECMO was instituted to maintain fetal oxygenation. We compared fetal blood gases and concentrations of atrial natriuretic peptide (ANP), epinephrine and norepinephrine with both routes of ECMO. Results: Fetal carotid artery pH did not change during hypoxemia, but decreased after instituting V-A ECMO and V-V ECMO. After instituting V-A ECMO or V-V ECMO for 30 min, oxygen partial pressure (pO2) in the fetal cranial carotid artery recovered from the hypoxic level. The ANP concentration in V-V ECMO was significantly lower than that in V-A ECMO. Fetal serum epinephrine and norepinephrine concentrations significantly increased in association with hypoxic stimulation. There was a further increase in fetal serum epinephrine concentration after instituting V-A ECMO. No significant difference in concentration was found after instituting V-V ECMO from that of after the institution of V-A ECMO. Conclusions: This study suggested that V-V ECMO may possibly be less invasive than V-A ECMO for fetal heart, because ANP, a cardiac distress index, was lower in V-V ECMO than in V-A ECMO. | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 58, 号 1, p. 9-16, 発行日 2012 |
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| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.58.9 | |||||||||||||||||
| 関連情報 | ||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||
| 関連識別子 | 22790887 | |||||||||||||||||
| 関連情報 | ||||||||||||||||||
| 識別子タイプ | ICHUSHI | |||||||||||||||||
| 関連識別子 | 2013201659 | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| 収録物識別子 | ||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||||||||
| 収録物識別子 | ||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||||||||
| 収録物識別子 | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA0065246X | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Extracorporeal membrane oxygenation (ECMO) | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | hypoxia | |||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||
| 主題 | fetus | |||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||
| 主題 | sheep | |||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||
| 主題 | atrial natriuretic peptide (ANP) | |||||||||||||||||
