{"created":"2024-11-29T09:26:56.793823+00:00","id":2001810,"links":{},"metadata":{"_buckets":{"deposit":"f12759a3-3470-498f-9305-b6940936bb98"},"_deposit":{"created_by":8,"id":"2001810","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2001810"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02001810","sets":["1732778801467:1732778962699:1732871851743"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"The endocrinological responses of veno-venous extracorporeal membrane oxygenation on hypoxic fetal lambs","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nomura, Yasuhisa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kato, Katsuhiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fujimori, Keiya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shiroto, Tomohiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishida, Tomohiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sato, Akira","creatorNameLang":"en"}]}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2012 The Fukushima Society of Medical Science","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Extracorporeal membrane oxygenation (ECMO)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hypoxia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fetus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sheep","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"atrial natriuretic peptide (ANP)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Objective: The purpose of this study was to observe endocrinological responses of veno-arterial and veno-venous extracorporeal membrane oxygenation (V-A and V-V ECMO) to support fetal oxygenation in utero. Methods: An ECMO system with a centrifugal pump was applied to six chronically instrumented fetal lambs, at 126-134 days of gestation. Blood was obtained through a double-lumen catheter inserted into the right atrium. After oxygenation, the blood was returned through a single-lumen catheter into either the carotid artery (veno-arterial; V-A ECMO) or the right atrium (V-V ECMO). After fetal hypoxia had been experimentally produced, V-A ECMO or V-V ECMO was instituted to maintain fetal oxygenation. We compared fetal blood gases and concentrations of atrial natriuretic peptide (ANP), epinephrine and norepinephrine with both routes of ECMO. Results: Fetal carotid artery pH did not change during hypoxemia, but decreased after instituting V-A ECMO and V-V ECMO. After instituting V-A ECMO or V-V ECMO for 30 min, oxygen partial pressure (pO2) in the fetal cranial carotid artery recovered from the hypoxic level. The ANP concentration in V-V ECMO was significantly lower than that in V-A ECMO. Fetal serum epinephrine and norepinephrine concentrations significantly increased in association with hypoxic stimulation. There was a further increase in fetal serum epinephrine concentration after instituting V-A ECMO. No significant difference in concentration was found after instituting V-V ECMO from that of after the institution of V-A ECMO. Conclusions: This study suggested that V-V ECMO may possibly be less invasive than V-A ECMO for fetal heart, because ANP, a cardiac distress index, was lower in V-V ECMO than in V-A ECMO.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"The Fukushima Society of Medical Science","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0016-2590","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2185-4610","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA0065246X","subitem_source_identifier_type":"NCID"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"16","bibliographicPageStart":"9","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"Fukushima Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5387/fms.58.9","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"22790887","subitem_relation_type_select":"PMID"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2013201659","subitem_relation_type_select":"ICHUSHI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2012-08-01"}],"displaytype":"detail","filename":"FksmJMedSci_58_p9.pdf","filesize":[{"value":"434.4 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2001810/files/FksmJMedSci_58_p9.pdf"},"version_id":"52926caf-4b22-47c7-a1dc-25438fa46f3a"}]},"item_title":"The endocrinological responses of veno-venous extracorporeal membrane oxygenation on hypoxic fetal lambs","item_type_id":"40002","owner":"8","path":["1732871851743"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-08-01"},"publish_date":"2012-08-01","publish_status":"0","recid":"2001810","relation_version_is_last":true,"title":["The endocrinological responses of veno-venous extracorporeal membrane oxygenation on hypoxic fetal lambs"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2025-01-09T09:03:52.565586+00:00"}