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Pharmacologic background and clinical issue of anti-influenza drugs
https://fmu.repo.nii.ac.jp/records/2002347
https://fmu.repo.nii.ac.jp/records/2002347abbfca80-0e5c-405d-90ab-2d4f9dc32fdb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FksmJMedSci_71_p1.pdf (1.2 MB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-01-29 | |||||||
| タイトル | ||||||||
| タイトル | Pharmacologic background and clinical issue of anti-influenza drugs | |||||||
| 言語 | en | |||||||
| 作成者 |
Sato, Masatoki
× Sato, Masatoki
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| 権利情報 | ||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |||||||
| 権利情報 | © 2025 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Since 2000, rapid antigen detection kits and anti-influenza drugs have been used for the early diagnosis and treatment of influenza in Japan, respectively. The main drugs available in clinical practice are the neuraminidase inhibitors oseltamivir, zanamivir, laninamivir, and peramivir, as well as the cap-dependent endonuclease inhibitor baloxavir marboxil. Antiviral therapy with neuraminidase inhibitors has been practiced for many years, especially in Japan; it can shorten the febrile period and reduce complications. Despite having similar structures, the pharmacologic background of neuraminidase inhibitors differs significantly, as reflected in their varying clinical efficacy. Due to its inhibitory mechanism, baloxavir marboxil can rapidly reduce the viral load than neuraminidase inhibitors. However, the duration of symptoms was similar after the administration of baloxavir marboxil and oseltamivir, and variants with reduced drug susceptibility have been detected in 20%-30% of pediatric patients treated with baloxavir marboxil. Clinical trials of several novel anti-influenza drugs are currently underway. When these drugs are first marketed, the characteristics of the influenza virus and the pharmacologic background of the drugs must be clarified before their administration to patients in clinical practice. | |||||||
| 出版者 | ||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 書誌情報 |
en : Fukushima journal of medical science 巻 71, 号 1, p. 1-12, 発行日 2025 |
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| 関連情報 | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.5387/fms.24-00029 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 39694499 | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 0016-2590 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 2185-4610 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA0065246X | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | anti-influenza drug | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | antiviral | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | influenza | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | children | |||||||
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| 主題Scheme | MeSH | |||||||
| 主題 | Humans | |||||||
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| 主題Scheme | MeSH | |||||||
| 主題 | Antiviral Agents | |||||||
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| 主題Scheme | MeSH | |||||||
| 主題 | Influenza, Human | |||||||
| 主題 | ||||||||
| 主題Scheme | MeSH | |||||||
| 主題 | Dibenzothiepins | |||||||
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| 主題Scheme | MeSH | |||||||
| 主題 | Pyridones | |||||||
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| 主題Scheme | MeSH | |||||||
| 主題 | Triazines | |||||||
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| 主題Scheme | MeSH | |||||||
| 主題 | Morpholines | |||||||
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| 主題Scheme | MeSH | |||||||
| 主題 | Thiepins | |||||||
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| 主題Scheme | MeSH | |||||||
| 主題 | Neuraminidase | |||||||
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| 主題Scheme | MeSH | |||||||
| 主題 | Oseltamivir | |||||||
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| 主題Scheme | MeSH | |||||||
| 主題 | Pyridines | |||||||
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| 主題Scheme | MeSH | |||||||
| 主題 | Pyrans | |||||||
