| Item type |
デフォルトアイテムタイプ（フル）fmu(1) |
| 公開日 |
2024-05-01 |
| タイトル |
|
|
タイトル |
Differentiation of ovarian serous carcinoma from ovarian clear cell carcinoma using a 10-gene signature selected by comprehensive gene expression analysis |
|
言語 |
en |
| 作成者 |
Nomura, Shinji
Watanabe, Takafumi
Honma, Reiko
Matsukura, Susumu
Ito, Emi
Imai, Jun-Ichi
Kiko, Yuichiro
Suzuki, Osamu
Hashimoto, Yuko
Kojima, Manabu
Furukawa, Shigenori
Soeda, Shu
Watanabe, Shinya
Fujimori, Keiya
|
| 権利情報 |
|
|
権利情報Resource |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
|
権利情報 |
© 2024 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aim: Ovarian serous carcinoma (OSC) and ovarian clear cell carcinoma (OCCC) are two major histological types of epithelial ovarian carcinoma (EOC), each with different biological features and clinical behaviors. Although immunostaining is commonly used for differential diagnosis between OSC and OCCC, correct identification of EOC with mixed-type histology is sometimes a diagnostic challenge. The aim of the present study was to explore candidate genes as potential diagnostic biomarkers that distinguish OSC from OCCC. Methods: A total of 57 surgical specimens were obtained from EOC patients who had previously undergone primary debulking surgery. Total RNAs were extracted from fresh-frozen tissues of EOC patients, and were used for comprehensive gene expression analysis using DNA microarray technology. Results: Ten candidate genes, FXYD2, TMEM101, GABARAPL1, ARG2, GLRX, RBPMS, GDF15, PPP1R3B, TOB1, and GSTM3 were up-regulated in OCCC compared to OSC. All EOC patients were divided into two groups according to hierarchical clustering using a 10-gene signature. Conclusion: Our data suggest that the 10 candidate genes would be an excellent marker for distinguishing OSC from OCCC. Furthermore, the molecular signatures of the 10 genes may enlighten us on the differences in carcinogenesis, and provide a theoretical basis for OCCC's resistance to chemotherapy in the future. |
| 出版者 |
|
|
出版者 |
The Fukushima Society of Medical Science |
| 言語 |
|
|
言語 |
eng |
| 書誌情報 |
en : Fukushima Journal of Medical Science
巻 70,
号 2,
p. 65-73,
発行日 2024
|
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.5387/fms.23-00011 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
38494731 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0016-2590 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2185-4610 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA0065246X |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
comprehensive gene expression analysis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
diagnosis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
gene signature |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
ovarian clear cell carcinoma |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
ovarian serous carcinoma |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Humans |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Female |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Ovarian Neoplasms |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Adenocarcinoma, Clear Cell |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Middle Aged |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Cystadenocarcinoma, Serous |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Aged |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Diagnosis, Differential |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Gene Expression Profiling |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Adult |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Biomarkers, Tumor |
FksmJMedSci_70_p65.pdf (1.6 MB)
