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Tau positron emission tomography in patients with cognitive impairment and suspected Alzheimer's disease
https://fmu.repo.nii.ac.jp/records/2002073
https://fmu.repo.nii.ac.jp/records/20020738c0b2ddc-4542-4d48-96c5-f98b6be00ac0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FksmJMedSci_69_p85.pdf (618.7 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||
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| 公開日 | 2023-08-16 | |||||||||
| タイトル | ||||||||||
| タイトル | Tau positron emission tomography in patients with cognitive impairment and suspected Alzheimer's disease | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Matsuda, Hiroshi
× Matsuda, Hiroshi
× Yamao, Tensho
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| 権利情報 | ||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |||||||||
| 権利情報 | © 2023 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Alzheimer's disease (AD) is diagnosed by the presence of both amyloid β and tau proteins. Recent advances in molecular PET imaging have made it possible to assess the accumulation of these proteins in the living brain. PET ligands have been developed that bind to 3R/4R tau in AD, but not to 3R tau or 4R tau alone. Of the first-generation PET ligands, 18F-flortaucipir has recently been approved by the Food and Drug Administration. Several second-generation PET probes with less off-target binding have been developed and are being applied clinically. Visual interpretation of tau PET should be based on neuropathological neurofibrillary tangle staging instead of a simple positive or negative classification. Four visual read classifications have been proposed: "no uptake," "medial temporal lobe (MTL) only," "MTL AND," and "outside MTL." As an adjunct to visual interpretation, quantitative analysis has been proposed using MRI-based native space FreeSurfer parcellations. The standardized uptake value ratio of the target area is measured using the cerebellar gray matter as a reference region. In the near future, the Centiloid scale of tau PET is expected to be used as a harmonized value for standardizing each analytical method or PET ligand used, similar to amyloid PET. | |||||||||
| 出版者 | ||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 69, 号 2, p. 85-93, 発行日 2023 |
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| 関連情報 | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.5387/fms.2023-08 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 37302841 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | ICHUSHI | |||||||||
| 関連識別子 | 2024315147 | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0016-2590 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 2185-4610 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA0065246X | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Alzheimer’s disease | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | PET | |||||||||
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| 主題Scheme | Other | |||||||||
| 主題 | tau | |||||||||
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| 主題Scheme | Other | |||||||||
| 主題 | amyloid | |||||||||
| 主題 | ||||||||||
| 主題Scheme | MeSH | |||||||||
| 主題 | Alzheimer Disease | |||||||||
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| 主題Scheme | MeSH | |||||||||
| 主題 | Amyloid beta-Peptides | |||||||||
| 主題 | ||||||||||
| 主題Scheme | MeSH | |||||||||
| 主題 | Cognitive Dysfunction | |||||||||
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| 主題Scheme | MeSH | |||||||||
| 主題 | Humans | |||||||||
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| 主題Scheme | MeSH | |||||||||
| 主題 | Ligands | |||||||||
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| 主題Scheme | MeSH | |||||||||
| 主題 | Positron-Emission Tomography | |||||||||
