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  1. 福島医学会
  2. Fukushima Journal of Medical Science
  3. Vol.68 (2022)

Successful management of pelvic recurrence of MSI-High endometrial cancer by total pelvic exenteration followed by administration of pembrolizumab:A case report

https://fmu.repo.nii.ac.jp/records/2002062
https://fmu.repo.nii.ac.jp/records/2002062
aaed1b7c-9c9c-4176-a4d9-2aefbdbcc0fd
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FksmJMedSci_68_p191.pdf FksmJMedSci_68_p191.pdf (768.6 KB)
Item type デフォルトアイテムタイプ(フル)fmu(1)
公開日 2022-12-23
タイトル
タイトル Successful management of pelvic recurrence of MSI-High endometrial cancer by total pelvic exenteration followed by administration of pembrolizumab:A case report
言語 en
作成者 Kojima, Manabu

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en Kojima, Manabu

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Soeda, Shu

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en Soeda, Shu

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Okabe, Chikako

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Sato, Tetsu

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Kamo, Norihito

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en Kamo, Norihito

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Ueda, Makiko

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Endo, Yuta

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Nomura, Shinji

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Tokuda, Emi

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Furukawa, Shigenori

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Kataoka, Masao

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Fujita, Shotaro

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Saji, Shigehira

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Watanabe, Takafumi

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Fujimori, Keiya

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権利情報
権利情報Resource https://creativecommons.org/licenses/by-nc-sa/4.0/
権利情報 © 2022 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
内容記述
内容記述タイプ Abstract
内容記述 Surgery can be curative treatment for pelvic locoregional recurrence of endometrial cancer; however, a cure is contingent on complete resection. Here, we report the case of a patient in whom recurrent endometrial tumor remained in the pelvis after resection; long-term control was achieved with postoperative administration of pembrolizumab.The patient had recurrent endometrial cancer of stage IA and was treated with chemotherapy and radiation, but tumor persisted in the pelvic cavity. We therefore attempted total pelvic exenteration, but the tumor was adherent to the pelvic wall and complete resection could not be achieved. However, postoperative administration of pembrolizumab controlled the residual tumor for more than two years without regrowth. We believe that since the resected tumor was MSI-High, the residual tumor responded well to pembrolizumab. It is not known whether cytoreductive surgery contributes to a long-term response to pembrolizumab, but at least in our patient, pembrolizumab appeared to be a very effective drug therapy for MSI-High endometrial cancer that was refractory to chemotherapy and radiotherapy.
出版者
出版者 The Fukushima Society of Medical Science
言語
言語 eng
書誌情報 en : Fukushima Journal of Medical Science

巻 68, 号 3, p. 191-195, 発行日 2022
関連情報
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.5387/fms.2022-10
関連情報
識別子タイプ PMID
関連識別子 36351631
関連情報
識別子タイプ ICHUSHI
関連識別子 2024061745
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0016-2590
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 2185-4610
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA0065246X
主題
主題Scheme Other
主題 Recurrent Endometrial Cancer
主題
主題Scheme Other
主題 Pelvic Exenteration
主題
主題Scheme Other
主題 Immune Checkpoint Inhibitor
主題
主題Scheme Other
主題 Pembrolizumab
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