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  1. 福島医学会
  2. Fukushima Journal of Medical Science
  3. Vol.66 (2020)

Exhaled carbon monoxide levels in infants and toddlers with episodic asthma

https://fmu.repo.nii.ac.jp/records/2002001
https://fmu.repo.nii.ac.jp/records/2002001
00e46611-6cf9-4c54-9794-078712060df9
名前 / ファイル ライセンス アクション
FksmJMedSci_66_p78.pdf FksmJMedSci_66_p78.pdf (881.6 KB)
Item type デフォルトアイテムタイプ(フル)fmu(1)
公開日 2020-09-03
タイトル
タイトル Exhaled carbon monoxide levels in infants and toddlers with episodic asthma
言語 en
作成者 Ohara, Yoichiro

× Ohara, Yoichiro

en Ohara, Yoichiro

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Ohara, Takahiro

× Ohara, Takahiro

en Ohara, Takahiro

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Hashimoto, Koichi

× Hashimoto, Koichi

en Hashimoto, Koichi

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Hosoya, Mitsuaki

× Hosoya, Mitsuaki

en Hosoya, Mitsuaki

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権利情報
権利情報Resource https://creativecommons.org/licenses/by-nc-sa/4.0/
権利情報 © 2020 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
内容記述
内容記述タイプ Abstract
内容記述 Objective: There are few lung function tests available to evaluate bronchial asthma in infants and toddlers. The objective of this study was to test the hypothesis that the measurement of exhaled carbon monoxide (eCO) levels is applicable to evaluate infants and toddlers with stable asthma and during acute asthma attack. Methods: A one-way valve breath sampling bag was developed to collect the exhaled air of infants and toddlers. A total of 483 infants (under 2 years) and toddlers (2-5 years) were studied; 355 had an established diagnosis of asthma (182 suffering mild asthma attacks and 173 without active asthmatic symptoms), 119 had upper respiratory infection (URI) including acute bronchitis, and 9 were healthy. Results: In infants and toddlers, eCO levels of those with asthma attacks [median (interquartile range) = 2.0 (2.0-3.25) ppm, n=182] were significantly higher than those of subjects with asymptomatic asthma [2.0 (1.0-2.0) ppm, n=173, P < 0.0001], URI [2.0 (1.0-3.0) ppm, n=119, P < 0.0001], and healthy children [1.0 (0.0-1.0) ppm, n=9, P < 0.0001]. In 75 children with asthma petit mal, eCO levels during asthma attacks [3.0 (2.0-4.0) ppm] significantly decreased after therapy [1.0 (1.0-2.0) ppm, P < 0.0001]. In infants and toddlers with an established diagnosis of asthma (n=355), eCO cut-off >2 ppm discriminated asthma attack from an asymptomatic state with a sensitivity of 95.6%, a specificity of 43.3%, and an area under the curve (AUC) of 0.71 (95% CI:0.65-0.76, P < 0.0001). In 401 infants and toddlers with some respiratory symptoms, of which 285 cases were finally diagnosed as asthma [eCO level = 2.0 (2.0-3.0) ppm] and 116 cases were not asthma [eCO level = 2.0 (1.0-3.0) ppm, P < 0.0001], eCO cut-off >3 ppm supported the final diagnosis of asthma with a sensitivity of 38.9%, a specificity of 74.1%, and AUC of 0.63 (95% CI:0.56-0.69, P < 0.0001). Conclusion: The measurement of eCO by a novel method is applicable to evaluate asthmatic activity and treatment responsiveness, and to diagnose asthma in infants and toddlers.
出版者
出版者 The Fukushima Society of Medical Science
言語
言語 eng
書誌情報 en : Fukushima Journal of Medical Science

巻 66, 号 2, p. 78-87, 発行日 2020
関連情報
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.5387/fms.2019-02
関連情報
識別子タイプ PMID
関連識別子 32595177
関連情報
識別子タイプ ICHUSHI
関連識別子 2021182238
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0016-2590
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 2185-4610
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA0065246X
主題
主題Scheme Other
主題 infants and toddlers
主題
主題Scheme Other
主題 mild asthma attack
主題
主題Scheme Other
主題 simple breath sampling method
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