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  1. 福島医学会
  2. Fukushima Journal of Medical Science
  3. Vol.66 (2020)

Autophagy is involved in the sclerotic phase of systemic sclerosis

https://fmu.repo.nii.ac.jp/records/2001992
https://fmu.repo.nii.ac.jp/records/2001992
859af95b-962b-461e-854f-d3a7536f1f87
名前 / ファイル ライセンス アクション
FksmJMedSci_66_p17.pdf FksmJMedSci_66_p17.pdf (2.5 MB)
Item type デフォルトアイテムタイプ(フル)fmu(1)
公開日 2020-06-16
タイトル
タイトル Autophagy is involved in the sclerotic phase of systemic sclerosis
言語 en
作成者 Mori, Tatsuhiko

× Mori, Tatsuhiko

en Mori, Tatsuhiko

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Tamura, Naoki

× Tamura, Naoki

en Tamura, Naoki

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Waguri, Satoshi

× Waguri, Satoshi

en Waguri, Satoshi

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Yamamoto, Toshiyuki

× Yamamoto, Toshiyuki

en Yamamoto, Toshiyuki

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権利情報
権利情報Resource https://creativecommons.org/licenses/by-nc-sa/4.0/
権利情報 © 2020 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
内容記述
内容記述タイプ Abstract
内容記述 Autophagy is an essential intracellular self-degradation system, and is known to maintain the homeostatic balance between the synthesis, degradation, and recycling of cellular proteins and organelles. Recent studies have suggested a possible role of autophagy in systemic sclerosis (SSc); however, differences in autophagy among pathological phases of SSc have not yet been examined. Therefore, in the current study we investigated the expression pattern of an autophagosome marker protein, microtubule-associated protein 1 light chain 3 (LC3) in the lesional skin of a murine model and human SSc. In bleomycin-induced mouse scleroderma skin, the number of LC3-positive puncta was significantly higher than that in phosphate buffered salts-injected control skin after 4 weeks of treatment. Such an increase, however, was not observed in the skin after 2 weeks of bleomycin treatment, in which few myofibroblasts were detected. In the sclerotic phase of SSc patients, the number of LC3-positive puncta in the lower dermis was significantly higher than in the upper dermis. It was also significantly higher than in the lower dermis of the control patients. No increase in LC3-positive puncta was observed in the skin from SSc patients in edematous phase, in which myofibroblasts were hardly detected. These results suggest that changes in the autophagic degradation system reflect a skin remodeling process that leads to fibrosis.
出版者
出版者 The Fukushima Society of Medical Science
言語
言語 eng
書誌情報 en : Fukushima Journal of Medical Science

巻 66, 号 1, p. 17-24, 発行日 2020
関連情報
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.5387/fms.2019-28
関連情報
識別子タイプ PMID
関連識別子 32281584
関連情報
識別子タイプ ICHUSHI
関連識別子 2020385344
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0016-2590
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 2185-4610
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA0065246X
主題
主題Scheme Other
主題 LC3
主題
主題Scheme Other
主題 lysosome
主題
主題Scheme Other
主題 scleroderma
主題
主題Scheme Other
主題 murine model
主題
主題Scheme Other
主題 bleomycin
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