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Autophagy is involved in the sclerotic phase of systemic sclerosis
https://fmu.repo.nii.ac.jp/records/2001992
https://fmu.repo.nii.ac.jp/records/2001992859af95b-962b-461e-854f-d3a7536f1f87
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FksmJMedSci_66_p17.pdf (2.5 MB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2020-06-16 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Autophagy is involved in the sclerotic phase of systemic sclerosis | |||||||||||||
| 言語 | en | |||||||||||||
| 作成者 |
Mori, Tatsuhiko
× Mori, Tatsuhiko
× Tamura, Naoki
× Waguri, Satoshi
× Yamamoto, Toshiyuki
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| 権利情報 | ||||||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |||||||||||||
| 権利情報 | © 2020 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Autophagy is an essential intracellular self-degradation system, and is known to maintain the homeostatic balance between the synthesis, degradation, and recycling of cellular proteins and organelles. Recent studies have suggested a possible role of autophagy in systemic sclerosis (SSc); however, differences in autophagy among pathological phases of SSc have not yet been examined. Therefore, in the current study we investigated the expression pattern of an autophagosome marker protein, microtubule-associated protein 1 light chain 3 (LC3) in the lesional skin of a murine model and human SSc. In bleomycin-induced mouse scleroderma skin, the number of LC3-positive puncta was significantly higher than that in phosphate buffered salts-injected control skin after 4 weeks of treatment. Such an increase, however, was not observed in the skin after 2 weeks of bleomycin treatment, in which few myofibroblasts were detected. In the sclerotic phase of SSc patients, the number of LC3-positive puncta in the lower dermis was significantly higher than in the upper dermis. It was also significantly higher than in the lower dermis of the control patients. No increase in LC3-positive puncta was observed in the skin from SSc patients in edematous phase, in which myofibroblasts were hardly detected. These results suggest that changes in the autophagic degradation system reflect a skin remodeling process that leads to fibrosis. | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 66, 号 1, p. 17-24, 発行日 2020 |
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| 関連情報 | ||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.2019-28 | |||||||||||||
| 関連情報 | ||||||||||||||
| 識別子タイプ | PMID | |||||||||||||
| 関連識別子 | 32281584 | |||||||||||||
| 関連情報 | ||||||||||||||
| 識別子タイプ | ICHUSHI | |||||||||||||
| 関連識別子 | 2020385344 | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA0065246X | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | LC3 | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | lysosome | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | scleroderma | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | murine model | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | bleomycin | |||||||||||||
