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Predictive factors for poor outcome in pediatric C3 glomerulonephritis
https://fmu.repo.nii.ac.jp/records/2001967
https://fmu.repo.nii.ac.jp/records/2001967b02c316e-5706-4fb2-9b11-8dbcc626f596
| 名前 / ファイル | ライセンス | アクション |
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FksmJMedSci_64_p142.pdf (775.3 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||||||||||
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| 公開日 | 2018-12-18 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Predictive factors for poor outcome in pediatric C3 glomerulonephritis | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 作成者 |
Hosoya, Mamiko
× Hosoya, Mamiko
× Kawasaki, Yukihiko
× Maeda, Ryo
× Sato, Masatoki
× Suyama, Kazuhide
× Hashimoto, Koichi
× Hosoya, Mitsuaki
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| 権利情報 | ||||||||||||||||||||
| 権利情報 | © 2018 The Fukushima Society of Medical Science | |||||||||||||||||||
| 内容記述 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Background: To clarify the predictive factors for poor outcome in pediatric C3 glomerulonephritis (C3GN), we retrospectively evaluated the relationship between the clinico-pathological findings and prognosis in cases of pediatric C3GN. Methods: We enrolled 18 patients diagnosed with C3GN. These patients were divided into two groups, four patients in the end-stage renal disease (ESRD) group and 14 patients in non-ESRD group, based on clinical status at the last examination. Patients in the non-ESRD group were further divided into Subgroup A, consisting of 6 treatment responders, and Subgroup B, consisting of 8 non- responders. The clinical and laboratory findings, as well as the histological findings were investigated for each group. Results: The frequency of nephrotic syndrome at onset in the ESRD group was higher than that in the non-ESRD group. Before treatment and at 2 years after treatment, urinary protein excretion levels and serum creatinine levels in the ESRD group were higher than those in the non-ESRD group. The mean serum C3 and CH50 levels at 2 years after treatment in the ESRD group were lower than those in the non-ESRD group. The degree of renal injury, level of mesangial deposits and degree of alpha SMA staining at the time of the first renal biopsy in the ESRD group were all higher than those in the non-ESRD group. Conclusions: Our results suggest that the severity of C3GN at onset and persistent complements activity are associated with poor prognosis in C3GN. | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 64, 号 3, p. 142-150, 発行日 2018 |
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| 関連タイプ | isIdenticalTo | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.2018-05 | |||||||||||||||||||
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| 識別子タイプ | PMID | |||||||||||||||||||
| 関連識別子 | 30369521 | |||||||||||||||||||
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| 識別子タイプ | ICHUSHI | |||||||||||||||||||
| 関連識別子 | 2020107749 | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA0065246X | |||||||||||||||||||
| 主題 | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | C3 glomerulonephritis | |||||||||||||||||||
| 主題 | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | epidemiology | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | clinic-pathological findings | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | predictive factors for poor outcome | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | children | |||||||||||||||||||
