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Comparisons between the efficacy of limaprost alfadex and pregabalin in cervical spondylotic radiculopathy : design of a randomized controlled trial
https://fmu.repo.nii.ac.jp/records/2001958
https://fmu.repo.nii.ac.jp/records/2001958bb1315c6-3af7-4e99-9088-e6f41840ddb3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FksmJMedSci_64_p73.pdf (350.7 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||
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| 公開日 | 2018-09-14 | |||||||||
| タイトル | ||||||||||
| タイトル | Comparisons between the efficacy of limaprost alfadex and pregabalin in cervical spondylotic radiculopathy : design of a randomized controlled trial | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Onda, Akira
× Onda, Akira
× Kimura, Masashi
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| 権利情報 | ||||||||||
| 権利情報 | © 2018 The Fukushima Society of Medical Science | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Background: Cervical spondylotic radiculopathy (CSR) is a relatively common neurological disease caused by the mechanical compression of nerve roots. Limaprost, a prostaglandin E1 derivative, functions as a vasodilator and has been used in the treatment of lumbar spinal stenosis in Japan. However, the effects of limaprost in cervical radiculopathy remain unclear. Our aim was to compare the efficacy of limaprost with that of pregabalin, which is widely used for the treatment of neuropathic pain. Methods: In this randomized trial, patients with CSR received either limaprost or pregabalin orally for 8 weeks, along with nonsteroidal anti-inflammatory drugs. The primary outcomes were assessed using a numerical rating scale of pain and numbness, both at rest and during movement. Secondary outcomes were assessed using Short Form-36, provocation tests, painDETECT questionnaire, and subjective global assessment. The obtained data were evaluated according to the per-protocol analysis principle. Results: A total of 46 patients were enrolled in this study, and 35 were available for analysis. A greater reduction in pain score was observed in neck pain during movement, and scapular and arm pain both at rest and during movement in the pregabalin-treated group up to 4 weeks. In the limaprost-treated group, numbness of the arm during movement showed a marked alleviation compared to the pregabalin-treated group at 8 weeks. There were no apparent differences between the two groups in terms of the secondary outcomes. Conclusions: Although pregabalin provided an earlier pain relief than limaprost, limaprost was superior to pregabalin in treating arm numbness. Limaprost might be one of the effective therapeutic options for CSR in primary care settings. | |||||||||
| 出版者 | ||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 64, 号 2, p. 73-81, 発行日 2018 |
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| 関連情報 | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.5387/fms.2018-07 | |||||||||
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| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 30012938 | |||||||||
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| 識別子タイプ | ICHUSHI | |||||||||
| 関連識別子 | 2020139715 | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0016-2590 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 2185-4610 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA0065246X | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | cervical radiculopathy | |||||||||
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| 主題Scheme | Other | |||||||||
| 主題 | limaprost | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | prostaglandin E1 and pregabalin | |||||||||
