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Successful therapy with tonsillectomy plus pulse therapy for the relapse of pediatric IgA nephropathy treated with multi-drugs combination therapy
https://fmu.repo.nii.ac.jp/records/2001917
https://fmu.repo.nii.ac.jp/records/2001917ca45e6b7-c7cf-4b3e-bff5-449c6716785f
| 名前 / ファイル | ライセンス | アクション |
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FksmJMedSci_62_p68.pdf (603.3 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||||||||||||
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| 公開日 | 2016-07-06 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Successful therapy with tonsillectomy plus pulse therapy for the relapse of pediatric IgA nephropathy treated with multi-drugs combination therapy | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 作成者 |
Sakai, Nobuko
× Sakai, Nobuko
× Kawasaki, Yukihiko
× Waragai, Tomoko
× Oikawa, Tomoko
× Kaneko, Masatoshi
× Sato, Tomoko
× Suyama, Kazuhide
× Hosoya, Mitsuaki
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| 権利情報 | ||||||||||||||||||||||
| 権利情報 | © 2016 The Fukushima Society of Medical Science | |||||||||||||||||||||
| 内容記述 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Immunoglobulin A nephropathy (IgAN) is the most common form of chronic glomerulonephritis worldwide. In Japan, the treatment for use as an initial therapy was established in Guidelines for the Treatment of Childhood IgA nephropathy; however, no rescue therapy for recurrent or steroid-resistant pediatric IgAN was established. We report here a 15-year-old boy with severe IgAN, who was treated with combination therapy involving prednisolone, mizoribine, warfarin, and dilazep dihydrochloride for 2 years. The response to the combination therapy was good and both proteinuria and hematuria disappeared. The pathological findings at the second renal biopsy were improved and PSL was discontinued. However, due to nonadherence to the treatment regimen and tonsillitis, macrohematuria and an increase of proteinuria were again observed and the pathological findings at the third renal biopsy showed clear deterioration. The patient was, therefore, diagnosed with recurrent IgAN. Tonsillectomy plus methylprednisolone pulse therapy (TMP) was performed as a rescue therapy for the recurrence of severe IgAN. Both the proteinuria or hematuria subsequently disappeared, and no proteinuria or hematuria has been observed and kidney function has remained normal during a 5-year follow-up. The patient experienced no severe side effects associated with the drug regimens. In conclusion, our case suggests that TMP may be an effective and useful rescue therapy for recurrent IgAN after multi-drug combination therapy. | |||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 62, 号 1, p. 68-73, 発行日 2016 |
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| 関連タイプ | isIdenticalTo | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.2016-3 | |||||||||||||||||||||
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| 識別子タイプ | PMID | |||||||||||||||||||||
| 関連識別子 | 27210310 | |||||||||||||||||||||
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| 識別子タイプ | ICHUSHI | |||||||||||||||||||||
| 関連識別子 | 2017326468 | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||
| 収録物識別子 | AA0065246X | |||||||||||||||||||||
| 主題 | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | IgA nephropathy | |||||||||||||||||||||
| 主題 | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | tonsillectomy plus pulse therapy | |||||||||||||||||||||
| 主題 | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | recurrence | |||||||||||||||||||||
| 主題 | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | multi-drugs combination therapy | |||||||||||||||||||||
| 主題 | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Mizoribine | |||||||||||||||||||||
