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Validation of therapeutic response assessment by bone scintigraphy in patients with bone-only metastatic breast cancers during zoledronic acid treatment: comparison with computed tomography assessment
https://fmu.repo.nii.ac.jp/records/2001890
https://fmu.repo.nii.ac.jp/records/20018906c9f314f-b209-4898-9487-c120b94ebafd
| 名前 / ファイル | ライセンス | アクション |
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FksmJMedSci_61_p23.pdf (673.4 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||||||
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| 公開日 | 2015-08-05 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Validation of therapeutic response assessment by bone scintigraphy in patients with bone-only metastatic breast cancers during zoledronic acid treatment: comparison with computed tomography assessment | |||||||||||||||
| 言語 | en | |||||||||||||||
| 作成者 |
Ishii, Shirou
× Ishii, Shirou
× Kikuchi, Ken
× Miyajima, Masayuki
× Sakuma, Kotaro
× Shishido, Fumio
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| 権利情報 | ||||||||||||||||
| 権利情報 | © 2015 The Fukushima Society of Medical Science | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Purpose: To validate the use of bone scintigraphy (BS) versus computed tomography (CT) for therapeutic monitoring in patients during treatment with zoledronic acid. Materials and Methods: Eleven patients with bone-only metastatic disease and being treated with zoledronic acid were included. The effects of therapies including chemotherapy and hormone therapy were evaluated in 25 separate examinations in total as follows: complete response (CR), when no bone metastasis was visible; partial response (PR), when a decrease in the lesion area was detected; stable disease (SD), when no or slight change was observed; and progressive disease (PD), when new or enlarged lesion areas were observed. Results: The accuracies of examination by Readers 1, 2, and 3 respectively were 76%, 80% and 76% for BS, 52%, 48%, and 40% for CT, and 64%, 52% and 60% for BS and CT combined with Readers 2 and 3 observing significant differences between CT and BS results. The rates of interobserver agreement between Readers 1 and 2, between Readers 1 and 3, and between Reader 2 and 3 respectively, were 84%, 80% and 88% (κ = 0.648, 0.561 and 0.766) for BS, 52%, 56%, and 60% (κ = 0.180, 0.278 and 0.282) for CT, and 52%, 60%, and 56% (κ = 0.215, 0.282 and 0.232) for CT and BS combined. Conclusion: BS is effective for assessing the response of bone metastasis to therapy in patients during zoledronic acid treatment. | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 61, 号 1, p. 23-31, 発行日 2015 |
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| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.2013-15 | |||||||||||||||
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| 識別子タイプ | PMID | |||||||||||||||
| 関連識別子 | 25946906 | |||||||||||||||
| 関連情報 | ||||||||||||||||
| 識別子タイプ | ICHUSHI | |||||||||||||||
| 関連識別子 | 2016216416 | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA0065246X | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | bone scintigraphy | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | computed tomography | |||||||||||||||
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| 主題Scheme | Other | |||||||||||||||
| 主題 | tumor marker | |||||||||||||||
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| 主題Scheme | Other | |||||||||||||||
| 主題 | bone metastases | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | therapeutic monitoring | |||||||||||||||
