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Prediction of recurrence for non-small cell lung cancer by combined analysis of molecular markers and ^{18}F 2-fluoro-2-deoxy-d-glucose positron emission tomography
https://fmu.repo.nii.ac.jp/records/2001856
https://fmu.repo.nii.ac.jp/records/20018569e938cf0-4568-4dde-8fff-af0158a545e6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FksmJMedSci_60_p47.pdf (770.9 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||||||||||||||
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| 公開日 | 2014-09-19 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Prediction of recurrence for non-small cell lung cancer by combined analysis of molecular markers and ^{18}F 2-fluoro-2-deoxy-d-glucose positron emission tomography | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 作成者 |
Yonechi, Atsushi
× Yonechi, Atsushi
× Suzuki, Hiroyuki
× Sakuma, Hideo
× Higuchi, Mitsunori
× Ohsugi, Jun
× Okabe, Naoyuki
× Muto, Satoshi
× Teranishi, Yasushi
× Gotoh, Mitsukazu
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| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | © 2014 The Fukushima Society of Medical Science | |||||||||||||||||||||||
| 内容記述 | ||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | [Purpose] Numerous biomarkers have been reported to reflect prognosis in patients with non-small cell lung cancer, but most of them remain controversial in terms of the clinical benefits. The aim of this study is to establish a novel procedure in combined analyses of molecular markers and biomedical image for precise prediction for patient prognosis of non-small cell lung cancer. [Experimental design] Molecular markers related to cell cycle and proliferation and ^{18}F 2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) were retrospectively analyzed for their utility as prognostic parameters in 54 patients with non-small cell lung cancer. Expression of ten representative molecular markers (Glut-1, proliferating cell nuclear antigen, Ki-67, cyclin B1, cyclin D1, cyclin E, E2F-1, p21, p27, and p53) were immunohistochemically analyzed using tissue microarray. The maximum standardized uptake value (SUVmax) on FDG-PET was analyzed as a semiquantitative value of FDG uptake of the primary tumor. [Results] Several molecular markers were significantly correlated with some of clinicopathological parameters, whereas none of each marker were correlated with recurrence or survival. Hierarchical clustering analysis in combination of immunohistochemical analysis of molecular expressions and SUVmax divided them into three subgroups significantly different in two-year recurrent-free survival (Cluster A, 56.3%; B, 100%; C 93.8%). These clustering subgroups were also significantly correlated with disease recurrence (p=0.0282). [Conclusions] Hierarchical clustering analysis, based on molecular markers and FDG accumulation, could be an efficient tool for prediction of recurrence and survival in patients with non-small cell lung cancer. | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 60, 号 1, p. 47-56, 発行日 2014-08-08 |
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| 関連タイプ | isIdenticalTo | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.2010-20 | |||||||||||||||||||||||
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| 識別子タイプ | PMID | |||||||||||||||||||||||
| 関連識別子 | 25030720 | |||||||||||||||||||||||
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| 識別子タイプ | ICHUSHI | |||||||||||||||||||||||
| 関連識別子 | 2015176972 | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA0065246X | |||||||||||||||||||||||
| 主題 | ||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | lung cancer | |||||||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | molecular markers | |||||||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | FDG-PET | |||||||||||||||||||||||
| 主題 | ||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | recurrence | |||||||||||||||||||||||
