| アイテムタイプ |
デフォルトアイテムタイプ（フル）fmu(1) |
| 公開日 |
2014-03-20 |
| タイトル |
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|
タイトル |
Suppression of advanced glycation and lipoxidation end products by Angiotensin ii type-1 receptor blocker candesartan in type 2 diabetic patients with essential hypertension |
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言語 |
en |
| 作成者 |
Ono, Yoshiaki
Mizuno, Kenji
Takahashi, Michihiko
Miura, Yukio
Watanabe, Tsuyoshi
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| 権利情報 |
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|
権利情報 |
© 2013 The Fukushima Society of Medical Science |
| 内容記述 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Objective: This study investigated whether the angiotensin II type-1 receptor blocker (ARB) candesartan affects markers of oxidative stress in type 2 diabetes mellitus (DM) patients with essential hypertension (EH).Methods: Urinary excretion of pyrraline (PR), pentosidine (PT), acrolein (AC), and 8-hydroxy-2'-deoxyguanosine (8-OH-dG) and microalbuminuria were assessed in patients with DM complicated by EH who were treated with candesartan 4 mg/day for 3 months.Results: In a total of 25 patients urinary excretion of PR (nmol/g· cr), PT (pmol/g· cr), and 8-OH-dG (ng/mg· cr) was significantly (all P < 0.05) decreased from (mean ± SEM) 11.9 ± 1.9, 30.6 ± 2.4, and 7.9 ± 0.6, respectively, at baseline to 8.4 ± 1.4, 27.1 ± 2.0, and 6.9 ± 0.6, respectively, at 3 months. Meanwhile, excretion of AC was unaltered from 209.6 ± 40.0 to 189 ± 24.8 nmol/mgcr (P = NS). Urinary albumin excretion was significantly (P < 0.05) reduced from 27.7 ± 4.6 to 14.1 ± 1.1 mg/g· cr. There were weak but statistically significant positive correlations between the change of urinary 8-OH-dG excretion and that of albumin (r = 0.414; P < 0.05) and change of hemoglobin (Hb) A1c (r = 0.45; P < 0.05).Conclusion: Candesartan exerts protective effect(s) on the cardiovascular system by suppression of oxidative stress-mainly through inhibiting production of advanced glycation end products (AGEs) rather than of advanced lipoxidation end products (ALEs)-in type 2 DM patients with EH. |
| 出版者 |
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|
出版者 |
The Fukushima Society of Medical Science |
| 言語 |
|
|
言語 |
eng |
| 書誌情報 |
en : Fukushima Journal of Medical Science
巻 59,
号 2,
p. 69-75,
発行日 2013
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| 関連情報 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.5387/fms.59.69 |
| 関連情報 |
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識別子タイプ |
PMID |
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|
関連識別子 |
24500381 |
| 関連情報 |
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|
識別子タイプ |
ICHUSHI |
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関連識別子 |
2015033198 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0016-2590 |
| 収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2185-4610 |
| 収録物識別子 |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA0065246X |
| 主題 |
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主題Scheme |
Other |
|
主題 |
type 2 diabetes mellitus (DM) |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
essential hypertension (EH) |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
candesartan |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
advanced glycation end products (AGEs) |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
advanced lipoxidation endproducts (ALEs) |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
microalbuminuria |
| 主題 |
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主題Scheme |
Other |
|
主題 |
oxidative stress |
FksmJMedSci_59_p69.pdf (364.2 KB)
