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Effect of oral L-arginine administration on exhaled nitric oxide (no) concentration in healthy volunteers
https://fmu.repo.nii.ac.jp/records/2001835
https://fmu.repo.nii.ac.jp/records/200183590abeb8b-5cd7-442d-8ab4-45064cfe05ee
| 名前 / ファイル | ライセンス | アクション |
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FksmJMedSci_59_p43.pdf (470.6 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||||||||||
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| 公開日 | 2013-08-15 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Effect of oral L-arginine administration on exhaled nitric oxide (no) concentration in healthy volunteers | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 作成者 |
Ogata, Hiroshi
× Ogata, Hiroshi
× Yatabe, Midori
× Misaka, Shingen
× Shikama, Yayoi
× Sato, Suguru
× Munakata, Mitsuru
× Kimura, Junko
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| 権利情報 | ||||||||||||||||||||
| 権利情報 | © 2013 The Fukushima Society of Medical Science | |||||||||||||||||||
| 内容記述 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | We previously reported a case of pulmonary hypertension, where the symptoms were improved by oral L-arginine (arginine) administration. Arginine may increase nitric oxide (NO) production in the pulmonary artery. Exhaled NO may reflect pulmonary artery NO production. It has been demonstrated that exhaled NO concentration is higher in patients with allergic diseases, but whether oral arginine administration alters exhaled NO is unknown. Therefore, in this study, we investigated whether oral arginine administration increases exhaled NO among healthy volunteers with and without a history of allergy.Eleven subjects were given a single oral dose (200 mg/kg) of arginine, and their plasma arginine concentrations and exhaled NO were measured up to 150 minutes. Baseline values of exhaled NO concentration were significantly higher in those with a history of allergy (56.4±20.3 ppb, n=5, P< 0.05) than those without (16.8±4.0 ppb, n=6). Oral arginine increased exhaled NO, which peaked at 60 minutes after the administration in those with a history of allergy (85.2±44.8 ppb, n=5). However, the increase in exhaled NO was not significant compared to the baseline values. In contrast, plasma arginine concentration was increased significantly by arginine administration (P< 0.01), regardless of an allergy history. These results suggested that the difference in exhaled NO concentration was not due to a difference in arginine absorption.Serum IgE level was significantly higher in the group with a history of allergy. Eosinophils and white blood cells were within normal range in all subjects. We conclude that oral arginine administration does not significantly increase exhaled NO, regardless of allergy history. However, as arginine administration has been reported to be effective in patients with pulmonary hypertension, it will be necessary to test exhaled NO in subjects with pulmonary hypertension in the future. | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 59, 号 1, p. 43-48, 発行日 2013 |
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| 関連タイプ | isIdenticalTo | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.59.43 | |||||||||||||||||||
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| 識別子タイプ | PMID | |||||||||||||||||||
| 関連識別子 | 23842514 | |||||||||||||||||||
| 関連情報 | ||||||||||||||||||||
| 識別子タイプ | ICHUSHI | |||||||||||||||||||
| 関連識別子 | 2014059600 | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA0065246X | |||||||||||||||||||
| 主題 | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Pulmonary hypertension | |||||||||||||||||||
| 主題 | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Healthy volunteers | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | L-Arginine | |||||||||||||||||||
| 主題 | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Exhaled NO | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Allergy | |||||||||||||||||||
