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Henoch-schönlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment
https://fmu.repo.nii.ac.jp/records/2001831
https://fmu.repo.nii.ac.jp/records/2001831b764a2e5-734e-4473-a924-31ef02c8efba
| 名前 / ファイル | ライセンス | アクション |
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FksmJMedSci_59_p15.pdf (310.8 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||||||||||
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| 公開日 | 2013-08-15 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Henoch-schönlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 作成者 |
Kawasaki, Yukihiko
× Kawasaki, Yukihiko
× Ono, Atsushi
× Ohara, Shinichiro
× Suzuki, Yuichi
× Suyama, Kazuhide
× Suzuki, Junzo
× Hosoya, Mitsuaki
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| 権利情報 | ||||||||||||||||||||
| 権利情報 | © 2013 The Fukushima Society of Medical Science | |||||||||||||||||||
| 内容記述 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and the deposition of IgA immune complexes. Renal involvement is the principal cause of morbidity and mortality in children with HSP. Thus, it is important to clarify the onset mechanism as well as the prognostic factors of Henoch-Schönlein purpura nephritis (HSPN) and to identify the most appropriate treatment. We herein review the pathogenesis, the prognostic factors and treatment of HSPN. As to the pathogenesis, several studies suggest that galactose-deficient IgA1 (Gd-IgA1) is recognized by anti-glycan antibodies, leading to the formation of circulating immune complexes and their mesangial deposition, thereby inducing renal injury. With regard to the prognostic factors, a number of factors have been suggested including nephrotic syndrome, decreased factor XIII activity, hypertension, severe renal injury, high renal accumulation of activated macrophage, alpha-smooth muscle actin, and high serum myeloid-related protein levels.For the treatment of severe HSPN, aggressive therapies including multiple drug combination therapy and plasmapheresis have been shown to be effective in ameliorating proteinuria and histological severity. Nevertheless, detailed investigation into the pathogenesis of HSPN and double-blind randomized control studies on children with HSPN are still necessary. | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 59, 号 1, p. 15-26, 発行日 2013 |
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| 関連タイプ | isIdenticalTo | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.59.15 | |||||||||||||||||||
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| 識別子タイプ | PMID | |||||||||||||||||||
| 関連識別子 | 23842510 | |||||||||||||||||||
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| 識別子タイプ | ICHUSHI | |||||||||||||||||||
| 関連識別子 | 2014059596 | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA0065246X | |||||||||||||||||||
| 主題 | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | HSPN | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Pathogenesis | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | urokinase pulse therapy | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | cyclophosphamide | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | mizoribine | |||||||||||||||||||
