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インデックスリンク
アイテム
Autoantibodies by line immunoassay in patients with primary biliary cirrhosis
https://fmu.repo.nii.ac.jp/records/2001825
https://fmu.repo.nii.ac.jp/records/2001825ecda97b5-3e15-44dd-80aa-61eb87189bc3
| 名前 / ファイル | ライセンス | アクション |
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FksmJMedSci_58_p107.pdf (389.7 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||||||||||||
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| 公開日 | 2012-12-25 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Autoantibodies by line immunoassay in patients with primary biliary cirrhosis | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 作成者 |
Saito, Hironobu
× Saito, Hironobu
× Takahashi, Atsushi
× Abe, Kazumichi
× Okai, Ken
× Katsushima, Fumiko
× Monoe, Kyoko
× Kanno, Yukiko
× Ohira, Hiromasa
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| 権利情報 | ||||||||||||||||||||||
| 権利情報 | © 2012 The Fukushima Society of Medical Science | |||||||||||||||||||||
| 内容記述 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Objectives: We attempted to measure multiple autoantibodies simultaneously using line immunoassay (LIA) in patients with primary biliary cirrhosis (PBC) with or without anti-mitochondrial antibody (AMA) and patients with PBC-autoimmune hepatitis (AIH) overlap, and we examined the clinical significance of measuring these autoantibodies. Methods: The study population consisted of 80 patients with PBC (including 12 AMA-negative patients), 16 patients with PBC-AIH overlap and 40 patients with AIH as controls. Nine antibodies (AMA-M2, M2-3E, Sp100, PML, gp210, Ro-52, LKM-1, LC-1 and SLA/LP) were detected by LIA, and AMA-M2 and anti-centromere antibody (ACA) were detected by ELISA. We examined the relationship between these autoantibodies and clinical findings. Results: The positive prevalence of each autoantibody and ACA in the PBC group, as determined by LIA, was as follows: 13.8% for anti-Sp100, 8.7% for anti-PML, 40% for anti-gp210 and 27.5% for anti-Ro-52 antibodies and 32.5% for ACA. In the PBC-AIH overlap group, the prevalence of anti-gp210 antibody (68.7%) and that of anti-Ro-52 antibody (81.2%) were significantly higher than those in the PBC and AIH groups. Only a few patients were positive for 2 or more autoantibodies. Nine patients were determined to be negative for all autoantibodies by LIA, of whom 7 were positive for ACA. Patients positive for anti-gp210 antibody included more patients classified as stage 4 on histology than did the negative group. Those positive for ACA included more patents with varices than did the negative group. Conclusion: LIA can measure multiple autoantibodies simultaneously and thus is considered useful in diagnosing PBC and PBC-AIH overlap. In addition, ACA is a useful marker for identifying AMA-negative PBC. | |||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 58, 号 2, p. 107-116, 発行日 2012 |
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| 関連タイプ | isIdenticalTo | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.58.107 | |||||||||||||||||||||
| 関連情報 | ||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||
| 関連識別子 | 23237866 | |||||||||||||||||||||
| 関連情報 | ||||||||||||||||||||||
| 識別子タイプ | ICHUSHI | |||||||||||||||||||||
| 関連識別子 | 2013249051 | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||
| 収録物識別子 | AA0065246X | |||||||||||||||||||||
| 主題 | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | primary biliary cirrhosis | |||||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | antimitochondrial antibody | |||||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | line immunoassay | |||||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | autoimmune hepatitis | |||||||||||||||||||||
