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The role of HMGA2 in the proliferation and expansion of a hematopoietic cell in myeloproliferative neoplasms
https://fmu.repo.nii.ac.jp/records/2001823
https://fmu.repo.nii.ac.jp/records/2001823f8de5278-b59f-4178-a7d4-230faeae6eb3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FksmJMedSci_58_p91.pdf (739.1 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||
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| 公開日 | 2012-12-25 | |||||||||||
| タイトル | ||||||||||||
| タイトル | The role of HMGA2 in the proliferation and expansion of a hematopoietic cell in myeloproliferative neoplasms | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
Ikeda, Kazuhiko
× Ikeda, Kazuhiko
× Ogawa, Kazuei
× Takeishi, Yasuchika
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| 権利情報 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報 | © 2012 The Fukushima Society of Medical Science | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are characterized by clonal proliferative hematopoiesis with increased blood cell count. Clonal expansion mechanisms in MPN and related disorders such as myelodysplastic syndromes (MDS) remain to be elucidated. Although mutations in the JAK2 gene lead to a proliferative hematopoiesis in majority of MPN and some MDS, the mutation alone does not cause a clonal expansion. In addition to JAK2 mutations, several genetic abnormalities, including TET2 and polycomb group genes involving epigenetic regulation have been reported in patients with MPN. Moreover, overexpression of HMGA2 due to removal of specific sites in its 3' untranslated region for regulatory let-7 micro RNAs may contribute to the proliferative hematopoiesis with conferring a growth advantage at the level of a hematopoietic stem cell in some cases with MPN. | |||||||||||
| 言語 | en | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 関連情報 | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.58.91 | |||||||||||
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| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 23237864 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | ICHUSHI | |||||||||||
| 関連識別子 | 2013249049 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA0065246X | |||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 58, 号 2, p. 91-100, 発行日 2012 |
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