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Interphase cytogenetic analysis of lung adenocarcinomas with bronchioloalveolar pattern
https://fmu.repo.nii.ac.jp/records/2001817
https://fmu.repo.nii.ac.jp/records/2001817ae0fb716-abbf-4ff7-aee7-e8dde8e1c1bd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FksmJMedSci_58_p66.pdf (1.0 MB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||
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| 公開日 | 2012-08-01 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Interphase cytogenetic analysis of lung adenocarcinomas with bronchioloalveolar pattern | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
Shimizu, Hajime
× Shimizu, Hajime
× Sugino, Takashi
× Chiba, Hideki
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| 権利情報 | ||||||||||||
| 権利情報 | © 2012 The Fukushima Society of Medical Science | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Aneuploidy has been suggested as a marker for stratification of many neoplasms but its potential usefulness in adenocarcinoma (ADC) with bronchioloalveolar (BAC) pattern has not been well defined. We examined paraffin-embedded tissue sections from 28 cases of ADC with BAC pattern as well as 7 benign lung lesions and 9 normal lung tissue samples for chromosomal aneuploidy by in situ hybridization using digoxigenin-labelled probes for chromosomes 1 and X. Of the 28 ADC with BAC pattern, 17 (61%) were diploid and 11 (39%) were aneuploid. Of the 17 diploid cases, 7 (41%) were male and 10 (59%) were female and of the 11 aneuploid cases, 2 (18%) were male, 9 (82%) were female. Regarding the cell type, 24 (86%) were adenocarcinomas in situ (AIS) so called BAC and minimally invasive ADC (MIA), and 4 cases (14%) were invasive ADC. Of the 12 cases each of AIS and MIA, 9 (75%) and 8 (67%) had diploid pattern respectively. Of the 4 invasive ADC cases, all had aneuploid pattern. Seventeen cases (71%) with T1 tumor size (> 0 mm∼≤30 mm), had diploid and 4 cases (100%) with T2 tumor size (> 30 mm ≤70 mm) had aneuploid pattern. Statistical analyses showed that nuclear diploidy was significantly correlated with AIS and MIA tumor types while aneuploidy correlated with invasive ADC type (P=0.025). Also a significant correlation was found between ploidy and tumor size (P=0.033). In conclusion, these findings suggest that DNA ploidy analysis provides useful information for the assessment of cellular kinetics and reflect histopathological subtypes in ADC with BAC pattern that are destined to behave aggressively. | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 58, 号 1, p. 66-73, 発行日 2012 |
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| 関連情報 | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.58.66 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 22790894 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | ICHUSHI | |||||||||||
| 関連識別子 | 2013201666 | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA0065246X | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Interphase cytogenetics | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | ploidy analysis | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | lung adenocarcinoma with bronchioloalveolar pattern | |||||||||||
