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Reinfection of cytomegalovirus in renal transplantation
https://fmu.repo.nii.ac.jp/records/2001793
https://fmu.repo.nii.ac.jp/records/2001793eede710e-1950-42a1-85f5-69e56d76edd5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FksmJMedSci_57_p1.pdf (533.6 KB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2011-07-05 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Reinfection of cytomegalovirus in renal transplantation | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
Ishibashi, Kei
× Ishibashi, Kei
× Yamaguchi, Osamu
× Suzutani, Tatsuo
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| 権利情報 | ||||||||||||
| 権利情報 | © 2011 The Fukushima Society of Medical Science | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Cytomegalovirus (CMV) is the most important pathogen affecting the outcome of renal transplantation. Reinfection of CMV can occur in CMV-seropositive donors and CMV seropositive recipients (D+/R+) settings because the protection against CMV conferred by preexisting immunity is limited due to its strain-dependent immune responses. To analyze the influence of CMV reinfection in renal transplantation, ELISA using fusion proteins encompassing epitope of glycoprotein H(gH) from both AD169 and Towne strains was employed before transplantation. The CMV-gH seropositive rate increased with increases in age and the rate of samples which contained antibodies against both AD169 and Towne were significantly high in the age of 50 years or over. Antibodies from HLA-DR10 and DR11 were associated with a significantly lower response rate against CMV-gH. In renal transplantation, the high degrees of antigenemia and high incidences of CMV disease are more prevalent in the CMV gH antibody-mismatched group in D+/R+ setting. The nucleotide sequence of the region of the gH epitope in the CMV-DNA extracted from the transplant recipients who showed high degree of antigenemia revealed the CMV reinfection from the donors. As a CMV indirect effect, the incidence of acute rejection in the mismatched gH antibody group was higher than that observed in the matched and D+/R- groups. The adverse events were more likely to occur in cases of D+/R+ renal transplantation with mismatched strain-specific antibodies which would indicates the risk of CMV reinfection after transplantation. | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 57, 号 1, p. 1-10, 発行日 2011 |
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| 関連情報 | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.57.1 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 21701077 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | ICHUSHI | |||||||||||
| 関連識別子 | 2013092314 | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA0065246X | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | cytomegalovirus | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | renal transplantation | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | glycoprotein H | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | reinfection | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Amino Acid Sequence | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Antibodies, Viral | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Base Sequence | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Cytomegalovirus | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Cytomegalovirus Infections | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Epitopes | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | HLA-DR Antigens | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | HLA-DR Serological Subtypes | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Humans | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Kidney Transplantation | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Molecular Sequence Data | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Viral Envelope Proteins | |||||||||||
