WEKO3
インデックスリンク
アイテム
Nitric oxide modulates biphasic contractile response of guinea pig vas deferens to electrical field stimulation
https://fmu.repo.nii.ac.jp/records/2001720
https://fmu.repo.nii.ac.jp/records/2001720b4092a5c-78a2-4bc3-924d-04278065d43b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FksmJMedSci_52_p45.pdf (790.8 KB)
|
|
| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2011-05-26 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Nitric oxide modulates biphasic contractile response of guinea pig vas deferens to electrical field stimulation | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
Nakanishi, Hironori
× Nakanishi, Hironori
× Matsuoka, Isao
× Nakahata, Norimichi
|
|||||||||||
| 権利情報 | ||||||||||||
| 権利情報 | © 2006 The Fukushima Society of Medical Science | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Electrical field stimulation (EFS) produced a biphasic contractile response; viz. initial rapid phasic contraction and second slow tonic contraction, in isolated guinea pig vas deferens. Pretreatment with the substrate of nitric oxide (NO) synthase (NOS), 1 mM L-arginine (L-ARG), augmented both the initial rapid and the second slow contractile responses to EFS (5 Hz, 0.5 msec, 30 V, for 30 sec). The increase of stimulation frequency from 5 Hz to 10 Hz or 20 Hz tended to attenuate the augmented responses. On the contrary, pretreatment with an inhibitor of NOS, 0.1 mM NG-nitro-L-arginine (L-NNA) suppressed both the initial rapid and the second slow contractile responses to EFS. The suppressive effect on the initial rapid contraction was also attenuated by the increase of stimulation frequency from 5 Hz or 10 Hz to 20 Hz. Contractile response to exogenously administered 1 mM adenosine triphosphate (ATP) tended to be slightly increased and decreased by the treatment with 1 mM L-ARG and 0.1 mM L-NNA, respectively. Contractile response to exogenously administered 10 microM noradrenaline (NA) was almost unaffected by the treatment with 1 mM L-ARG, while the treatment with 0.1 mM L-NNA slightly depressed the response. Potentiated contractile response to 1 mM ATP in the presence of 10 microM NA was further potentiated by the treatment with 1 mM L-ARG, while the response was almost unaffected by the treatment with 0.1 mM L-NNA. These findings may indicate that NO acts mainly on presynaptic site and increases the release of chemical transmitter, ATP or prevents the inactivation of ATP. Also, NO may act, at least in part, on postsynaptic site and potentiates the contractile response to ATP in the presence of NA. | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 52, 号 2, p. 45-57, 発行日 2006-12 |
|||||||||||
| 関連情報 | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.5387/fms.52.45 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 17427755 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | ICHUSHI | |||||||||||
| 関連識別子 | 2007203246 | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 0016-2590 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 2185-4610 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA0065246X | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Noradrenaline | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Guinea pig vas deferens | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Electrical field stimulation | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Adenosine Triphosphate | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Animals | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Arginine | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Electric Stimulation | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Guinea Pigs | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Male | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Muscle Contraction | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | NG-Nitroarginine Methyl Ester | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Nitric Oxide | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Nitroarginine | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | MeSH | |||||||||||
| 主題 | Vas Deferens | |||||||||||
