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Histogenesis of CD5-positive and CD5-negative B-cell neoplasms on the aspect of somatic mutation of immunoglobulin heavy chain gene variable region
https://fmu.repo.nii.ac.jp/records/2001678
https://fmu.repo.nii.ac.jp/records/200167826cb6e11-7118-410d-b4ab-7c2d75adadcc
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FksmJMedSci_49_p55.pdf (1.2 MB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||
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| 公開日 | 2011-05-25 | |||||||||
| タイトル | ||||||||||
| タイトル | Histogenesis of CD5-positive and CD5-negative B-cell neoplasms on the aspect of somatic mutation of immunoglobulin heavy chain gene variable region | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Nakamura, Naoya
× Nakamura, Naoya
× Abe, Masafumi
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| 権利情報 | ||||||||||
| 権利情報 | © 2003 The Fukushima Society of Medical Science | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The immunoglobulin heavy chain (IgH) gene of B-cells dramatically alters twice in their differentiation to memory or plasma cells; VDJ recombination at B-cell precursor and somatic hypermutation, class switch recombination and receptor revision at germinal center (GC) B-cells. Among them, somatic hypermutation of the IgH gene variable region (VH gene) is a powerful tool for detection of B cell differentiation. B-cells and B-cell neoplasms have been divided into following; 1) pre-GC B-cells and neoplasms with a germline VH gene and 2) GC and post-GC B-cells and neoplasms with a somatically mutated VH gene. In this article, we review normal B-cell differentiation and histogenesis of various types of B-cell neoplasms on the aspect of somatic mutation of the rearranged VH gene. In particular, differences between CD5+ and CD5- B-cell neoplasms, using our own data of over 100 cases with B-cell neoplasms, are discussed. Although CD5+ B-cells are included in pre-GC B-cells for the reason of germline VH gene in most of CD5+ B-cells, an about 5% of CD5+ B-cells show somatically mutated VH gene. The rearranged VH gene of CD5+ B-cell neoplasms shows heterogeneity, whereas CD5- B-cell neoplasms possess somatically mutated VH gene with a mean of 8 approximately 12%. Both CD5+ B-cell chronic lymphocytic leukemia and CD5+ diffuse large B-cell lymphoma display that about half of cases show a germline or low frequency of somatic mutation and the others possess somatically mutated VH gene. CD5+ mantle cell lymphoma constitutes most cases with germline and a small number of cases with mutated VH gene. Therefore, CD5- B-cells & CD5- B-cell neoplasms are distinct from CD5+ B-cells and CD5+ B-cell neoplasms in somatic mutation of VH gene. It suggests that each of CD5- and CD5+ B-cells independently has its own differentiation. | |||||||||
| 出版者 | ||||||||||
| 出版者 | The Fukushima Society of Medical Science | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 書誌情報 |
en : Fukushima Journal of Medical Science 巻 49, 号 2, p. 55-67, 発行日 2003-12 |
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| 関連情報 | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.5387/fms.49.55 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 15065636 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | ICHUSHI | |||||||||
| 関連識別子 | 2005187792 | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0016-2590 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 2185-4610 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA0065246X | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | immunoglobulin heavy chain gene | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | somatic mutation | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | B-cell | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | lymphoma | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | PCR | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | CD5 | |||||||||
| 主題 | ||||||||||
| 主題Scheme | MeSH | |||||||||
| 主題 | Antigens, CD5 | |||||||||
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| 主題Scheme | MeSH | |||||||||
| 主題 | B-Lymphocytes | |||||||||
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| 主題Scheme | MeSH | |||||||||
| 主題 | Cell Differentiation | |||||||||
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| 主題Scheme | MeSH | |||||||||
| 主題 | Genes, Immunoglobulin | |||||||||
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| 主題Scheme | MeSH | |||||||||
| 主題 | Humans | |||||||||
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| 主題Scheme | MeSH | |||||||||
| 主題 | Leukemia, B-Cell | |||||||||
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| 主題Scheme | MeSH | |||||||||
| 主題 | Lymphoma, B-Cell | |||||||||
| 主題 | ||||||||||
| 主題Scheme | MeSH | |||||||||
| 主題 | Somatic Hypermutation, Immunoglobulin | |||||||||
