| アイテムタイプ |
デフォルトアイテムタイプ（フル）fmu(1) |
| 公開日 |
2011-05-25 |
| タイトル |
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|
タイトル |
Adhesion molecules and CXC chemokines in endotoxin-induced liver injury |
|
言語 |
en |
| 作成者 |
Ohira, Hiromasa
Abe, Kazumichi
Yokokawa, Junko
Takiguchi, Junko
Rai, Tsuyoshi
Shishido, Shoichiro
Sato, Yukio
|
| 権利情報 |
|
|
権利情報 |
© 2003 The Fukushima Society of Medical Science |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Interactions between leukocytes and sinusoidal endothelial cells are known to be involved in the pathogenesis of acute liver injury. Various adhesion molecules and chemokines play key roles in these cell-to-cell interactions, and the expression of these adhesion molecules and the production of chemokines are regulated by inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and interferon-gamma (IFN-gamma). We have shown that the expression of intercellular adhesion molecule-1 (ICAM-1) on cultured rat sinusoidal endothelial cells stimulated with TNF-alpha increases in a dose-dependent manner. The number of neutrophils that adhered to sinusoidal endothelial cells pretreated with TNF-alpha also increased in a dose-dependent manner and significantly decreased upon incubation with an anti-ICAM-1 antibody. In endotoxin-induced rat liver injury, the number of neutrophils infiltrating the sinusoids increased after serum TNF-alpha, macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant (CINC) reached their peak levels. In addition, the level of ICAM-1 expression on sinusoidal endothelial cells greatly increased from 8 h after exposure to endotoxin, and these cells were adhered to neutrophils that expressed both LFA-1 and Mac-1. Moreover, lipo-prostaglandin E1 (PGE1) reduced the extent of liver injury, and also reduced the number of neutrophils that infiltrated the liver, was reduced the production of MIP-2 and CINC, but not that of TNF-alpha, in rats injected with endotoxin. |
| 出版者 |
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|
出版者 |
The Fukushima Society of Medical Science |
| 言語 |
|
|
言語 |
eng |
| 書誌情報 |
en : Fukushima Journal of Medical Science
巻 49,
号 1,
p. 1-13,
発行日 2003-06
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| 関連情報 |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.5387/fms.49.1 |
| 関連情報 |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
14603947 |
| 関連情報 |
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|
識別子タイプ |
ICHUSHI |
|
|
関連識別子 |
2004242919 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0016-2590 |
| 収録物識別子 |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2185-4610 |
| 収録物識別子 |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA0065246X |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
ICAM-1 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
MIP-2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
CINC |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
lipo-PGE1 |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Alprostadil |
| 主題 |
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|
主題Scheme |
MeSH |
|
主題 |
Animals |
| 主題 |
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|
主題Scheme |
MeSH |
|
主題 |
Chemokine CXCL2 |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Chemokines, CXC |
| 主題 |
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|
主題Scheme |
MeSH |
|
主題 |
Endothelial Cells |
| 主題 |
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|
主題Scheme |
MeSH |
|
主題 |
Endotoxins |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Intercellular Adhesion Molecule-1 |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Intercellular Signaling Peptides and Proteins |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Liver |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Monokines |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Neutrophils |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Rats |
| 主題 |
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|
主題Scheme |
MeSH |
|
主題 |
Tumor Necrosis Factor-alpha |
FksmJMedSci_49_p1.pdf (1.1 MB)
