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Tissue Hypoperfusion, Hypercoagulopathy, and Kidney and Liver Dysfunction after Ingestion of a Naphazoline-Containing Antiseptic
https://fmu.repo.nii.ac.jp/records/2000038
https://fmu.repo.nii.ac.jp/records/2000038e0576e47-3527-4608-b6ee-e077b2138188
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
CaseRepEmergMed_3968045.pdf (1.3 MB)
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| Item type | デフォルトアイテムタイプ（フル）fmu(1) | |||||||||||
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| 公開日 | 2017-05-18 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Tissue Hypoperfusion, Hypercoagulopathy, and Kidney and Liver Dysfunction after Ingestion of a Naphazoline-Containing Antiseptic | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
Ono, Yuko
× Ono, Yuko
× Ono, Nozomi
× Shinohara, Kazuaki
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| 権利情報 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報Resource | http://creativecommons.org/licenses/by/4.0/ | |||||||||||
| 権利情報 | © 2017 Yuko Ono et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Naphazoline is a peripheral 𝛼2-adrenergic receptor agonist commonly used as a topical decongestant. In Japan, over-thecounter antiseptics often contain naphazoline to effect local hemostasis. We present the first case involving the development of hypercoagulopathy, with kidney and liver dysfunction, following a naphazoline overdose. A 22-year-old Japanese woman with a history of depression ingested 160mL of a commercially available antiseptic containing 0.1% naphazoline. Three days later, she was brought to the emergency department because of general fatigue, nausea, and vomiting. Physical examination revealed cool, pale extremities. Laboratory data showed evidence of severe kidney and liver dysfunction (creatinine, 9.2mg/dL; alanine aminotransferase, 2948 IU/L), hypercoagulation (D-dimers, 58.3 𝜇g/mL), and thrombocytopenia (platelet count, 90,000/𝜇L). After infusion of normal saline, intravenous administration of alprostadil, and hemodiafiltration, her organ function completely recovered. Because both the kidney and liver express 𝛼2-adrenergic receptors, their failure was likely associated with naphazoline overdose-induced hypoperfusion. The most plausible causes of hypercoagulation are peripheral low perfusion and subsequent microthrombus formation. This case illustrates that severe organ dysfunction can occur following over-the-counter antiseptic ingestion and serves as a caution for both drug manufacturers and healthcare professionals. | |||||||||||
| 言語 | en | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Hindawi | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 関連情報 | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1155/2017/3968045 | |||||||||||
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| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 28555165 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 2090-648X | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 2090-6498 | |||||||||||
| 書誌情報 |
en : Case reports in emergency medicine 巻 2017, p. 3968045, 発行日 2017-05-07 |
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