| Item type |
デフォルトアイテムタイプ（フル）fmu(1) |
| 公開日 |
2010-06-08 |
| タイトル |
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タイトル |
High Serum Level of Pentosidine, an Advanced Glycation End Product (AGE), is a Risk Factor of Patients with Heart Failure |
|
言語 |
en |
| 作成者 |
Koyama, Yo
Takeishi, Yasuchika
Arimoto, Takanori
Niizeki, Takeshi
Shishido, Tetsuro
Takahashi, Hiroki
Nozaki, Naoki
Hirono, Osamu
Tsunoda, Yuichi
Nitobe, Joji
Watanabe, Tetsu
Kubota, Isao
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| 権利情報 |
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権利情報 |
Copyright © 2007 Elsevier Inc. All rights reserved. |
| 内容記述 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: Pentosidine, one of the advanced glycation end products (AGE), is generated by nonenzymatic glycation and oxidation of proteins. The receptor of AGE (RAGE) is expressed in a variety of tissue, and interaction of AGE with RAGE induces oxidative stress and activation of intracellular signaling causing production of cytokines and mediators of inflammation. We investigated whether serum pentosidine is a risk factor for heart failure. Methods: Serum pentosidine concentration was measured in 141 patients with heart failure and 18 control subjects by a competitive enzyme-linked immunosorbent assay. Patients were prospectively followed during a median follow-up period of 479 days with endpoints of cardiac death or re-hospitalization. Results: Serum concentration of pentosidine was significantly higher in NYHA class III/IV patients than in NYHA class I/II patients (P < 0.0001). Serum pentosidine was also higher in patients with cardiac events than in event free patients (P < 0.001). In the univariate Cox proportional hazard analysis, age, NYHA class, pentosidine, creatinine, uric acid, B-type natriuretic peptide, left ventricular end-systolic volume and left ventricular mass were significant risk factors to predict cardiac events. In the multivariate Cox analysis, serum pentosidine concentration was an independent risk factor for cardiac events (hazard ratio 1.88, 95% confidence interval 1.23 . 2.69, P = 0.002). Patients were divided into 4 groups based on the serum pentosidine levels. The highest 4th quartile of pentosidine was associated with the highest risk of cardiac events (4.52-fold). Conclusions: Serum pentosidine concentration is an independent prognostic factor for heart failure, and this new marker may be useful for risk stratification of patients with heart failure. |
| 出版者 |
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出版者 |
Elsevier Inc. |
| 言語 |
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|
言語 |
eng |
| 書誌情報 |
en : Journal of Cardiac Failure
巻 13,
号 3,
p. 199-206,
発行日 2007-04
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| 関連情報 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.cardfail.2006.11.009 |
| 関連情報 |
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識別子タイプ |
PMID |
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関連識別子 |
17448417 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1071-9164 |
| 収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1532-8414 |
| 収録物識別子 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11054062 |
| 主題 |
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主題Scheme |
Other |
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主題 |
pentosidine |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
Advanced glycation end products (AGE) |
| 主題 |
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|
主題Scheme |
MeSH |
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主題 |
Aged |
| 主題 |
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|
主題Scheme |
MeSH |
|
主題 |
Arginine |
| 主題 |
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|
主題Scheme |
MeSH |
|
主題 |
Biological Markers |
| 主題 |
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|
主題Scheme |
MeSH |
|
主題 |
Cardiotonic Agents |
| 主題 |
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|
主題Scheme |
MeSH |
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主題 |
Case-Control Studies |
| 主題 |
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|
主題Scheme |
MeSH |
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主題 |
Comorbidity |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Diabetes Complications |
| 主題 |
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|
主題Scheme |
MeSH |
|
主題 |
Digoxin |
| 主題 |
|
|
主題Scheme |
MeSH |
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主題 |
Diuretics |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Female |
| 主題 |
|
|
主題Scheme |
MeSH |
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主題 |
Follow-Up Studies |
| 主題 |
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主題Scheme |
MeSH |
|
主題 |
Heart Failure |
| 主題 |
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|
主題Scheme |
MeSH |
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主題 |
Hospitalization |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Humans |
| 主題 |
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|
主題Scheme |
MeSH |
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主題 |
Japan |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Kidney Failure |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Lysine |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Male |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Middle Aged |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Multivariate Analysis |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Prognosis |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Proportional Hazards Models |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Prospective Studies |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Risk Factors |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Sensitivity and Specificity |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Severity of Illness Index |
| 主題 |
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主題Scheme |
MeSH |
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主題 |
Survival Analysis |
JCardFail_13_p199.pdf (342.2 KB)
