{"created":"2025-01-29T04:56:39.951957+00:00","id":2002351,"links":{},"metadata":{"_buckets":{"deposit":"98daada2-ecf3-4f63-9838-7769838162fe"},"_deposit":{"created_by":8,"id":"2002351","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2002351"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02002351","sets":["1732778801467:1732778962699:1731396903214"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Therapeutic Agents and Patient Characteristics Affecting Metabolism of Thiopurines in Patients with Inflammatory Bowel Disease.","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Aizawa, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suzuki, Kohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakajima, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Utano, Kenichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tamazawa, Kana","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ueda, Kenta","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Wada, Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sato, Kentaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shibukawa, Goro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Noriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Togashi, Kazutomo","creatorNameLang":"en"}]}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2025 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-sa/4.0/"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Thiopurine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"6-TGN","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"6-MMP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammatory bowel disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Female","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Adult","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Mercaptopurine","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Middle Aged","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Inflammatory Bowel Diseases","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Aged","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Guanine Nucleotides","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Thionucleotides","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Mesalamine","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Allopurinol","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Young Adult","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Pyrophosphatases","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Nudix Hydrolases","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"OBJECTIVES: In inflammatory bowel disease therapy, thiopurines have been essential. However, several reports have investigated factors affecting thiopurine metabolism to date. This study investigated factors affecting intracellular concentrations of 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP) in a real-world setting. METHODS: Between May 2013 and October 2021 in one institution, 44 patients (median age 44 years;male 35, female 9;ulcerative colitis 32, Crohn's disease 12) receiving thiopurines were reviewed. Intracellular 6-TGN/6-MMP concentrations were measured by high-performance liquid chromatography, and the initial measurement in each patient was used for the study. RESULTS: The 6-TGN level was significantly higher in females, with mild disease activity, absence of NUDT15 polymorphism, and allopurinol administration. A higher trend was observed with high thiopurine dosage (>50 mg). 6-MMP levels were significantly lower with concomitant use of time-dependent 5-aminosalicylic acid (5-ASA) and allopurinol, and higher with high thiopurine dosage. On multivariate analysis of variance, logarithmically transformed 6-TGN levels were significantly higher in females, with high thiopurine dosage, and allopurinol administration. Similarly, logarithmically transformed 6-MMP levels were significantly higher with time-dependent 5-ASA administration and high thiopurine dosage. CONCLUSIONS: Patients who received allopurinol, a high dose of thiopurine, or were female showed higher 6-TGN levels.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"The Fukushima Society of Medical Science","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0016-2590","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2185-4610","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA0065246X","subitem_source_identifier_type":"NCID"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2025","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"55","bibliographicPageStart":"47","bibliographicVolumeNumber":"71","bibliographic_titles":[{"bibliographic_title":"Fukushima journal of medical science","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5387/fms.24-00009","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"39662937","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-01-29"}],"displaytype":"detail","filename":"FksmJMedSci_71_p47.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2002351/files/FksmJMedSci_71_p47.pdf"},"version_id":"ee6c4acb-7bcd-4c6c-8e02-6a01f677ae4a"}]},"item_title":"Therapeutic Agents and Patient Characteristics Affecting Metabolism of Thiopurines in Patients with Inflammatory Bowel Disease.","item_type_id":"40002","owner":"8","path":["1731396903214"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-01-29"},"publish_date":"2025-01-29","publish_status":"0","recid":"2002351","relation_version_is_last":true,"title":["Therapeutic Agents and Patient Characteristics Affecting Metabolism of Thiopurines in Patients with Inflammatory Bowel Disease."],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2025-01-29T05:07:40.538837+00:00"}