| Item type |
デフォルトアイテムタイプ（フル）fmu(1) |
| 公開日 |
2025-01-29 |
| タイトル |
|
|
タイトル |
Therapeutic Agents and Patient Characteristics Affecting Metabolism of Thiopurines in Patients with Inflammatory Bowel Disease. |
|
言語 |
en |
| 作成者 |
Aizawa, Masato
Suzuki, Kohei
Nakajima, Yuki
Utano, Kenichi
Tamazawa, Kana
Ueda, Kenta
Wada, Jun
Sato, Kentaro
Shibukawa, Goro
Tanaka, Noriko
Togashi, Kazutomo
|
| 権利情報 |
|
|
権利情報Resource |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
|
権利情報 |
© 2025 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
OBJECTIVES: In inflammatory bowel disease therapy, thiopurines have been essential. However, several reports have investigated factors affecting thiopurine metabolism to date. This study investigated factors affecting intracellular concentrations of 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP) in a real-world setting. METHODS: Between May 2013 and October 2021 in one institution, 44 patients (median age 44 years;male 35, female 9;ulcerative colitis 32, Crohn's disease 12) receiving thiopurines were reviewed. Intracellular 6-TGN/6-MMP concentrations were measured by high-performance liquid chromatography, and the initial measurement in each patient was used for the study. RESULTS: The 6-TGN level was significantly higher in females, with mild disease activity, absence of NUDT15 polymorphism, and allopurinol administration. A higher trend was observed with high thiopurine dosage (>50 mg). 6-MMP levels were significantly lower with concomitant use of time-dependent 5-aminosalicylic acid (5-ASA) and allopurinol, and higher with high thiopurine dosage. On multivariate analysis of variance, logarithmically transformed 6-TGN levels were significantly higher in females, with high thiopurine dosage, and allopurinol administration. Similarly, logarithmically transformed 6-MMP levels were significantly higher with time-dependent 5-ASA administration and high thiopurine dosage. CONCLUSIONS: Patients who received allopurinol, a high dose of thiopurine, or were female showed higher 6-TGN levels. |
| 出版者 |
|
|
出版者 |
The Fukushima Society of Medical Science |
| 言語 |
|
|
言語 |
eng |
| 書誌情報 |
en : Fukushima journal of medical science
巻 71,
号 1,
p. 47-55,
発行日 2025
|
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.5387/fms.24-00009 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
39662937 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0016-2590 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2185-4610 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA0065246X |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Thiopurine |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
6-TGN |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
6-MMP |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
inflammatory bowel disease |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Humans |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Female |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Male |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Adult |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Mercaptopurine |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Middle Aged |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Inflammatory Bowel Diseases |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Aged |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Guanine Nucleotides |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Thionucleotides |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Mesalamine |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Allopurinol |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Young Adult |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Pyrophosphatases |
| 主題 |
|
|
主題Scheme |
MeSH |
|
主題 |
Nudix Hydrolases |
FksmJMedSci_71_p47.pdf (1.1 MB)
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