{"created":"2024-12-06T09:01:11.725538+00:00","id":2002246,"links":{},"metadata":{"_buckets":{"deposit":"2ec5475c-8b09-4c70-8393-e52afa737165"},"_deposit":{"created_by":8,"id":"2002246","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2002246"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02002246","sets":["1732778801467:1733287270801:1733474562539:1733474801169"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"核内受容体の新規調節機構の発見と病理学への展開","subitem_title_language":"ja"}]},"item_1617186385884":{"attribute_name":"Alternative Title","attribute_value_mlt":[{"subitem_alternative_title":"A novel signaling pathway linking cell-cell adhesion to nuclear receptors","subitem_alternative_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorAlternatives":[{"creatorAlternative":"Sugimoto, Kotaro","creatorAlternativeLang":"en"}],"creatorNames":[{"creatorName":"杉本, 幸太郎","creatorNameLang":"ja"}]},{"creatorAlternatives":[{"creatorAlternative":"Chiba, Hideki","creatorAlternativeLang":"en"}],"creatorNames":[{"creatorName":"千葉, 英樹","creatorNameLang":"ja"}]}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2023 福島医学会","subitem_rights_language":"ja"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"核内受容体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞間接着","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"子宮体癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"乳癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"上皮分化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Nuclear receptors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell-cell adhesion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endometrial cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"breast cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"epithelial differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"核内受容体は様々な脂質を天然リガンドとする転写因子で，ヒトではレチノイン酸受容体，ビタミンD受容体，性ホルモン受容体，副腎皮質ホルモン受容体，および甲状腺ホルモン受容体など48種類が同定されている。核内受容体の転写活性は，基本的には特異リガンドとの結合によって調節されているが，実際にはリン酸化などの翻訳後修飾も影響する。我々は最近，細胞間接着から核内受容体のセリンリン酸化に至る新規のシグナル伝達経路を発見し，これが幹細胞分化および子宮体癌と乳癌の悪性形質増強に寄与することを明らかにした。本総説ではその一連の研究を紹介する。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Nuclear receptors are transcription factors that recognize various lipids as natural ligands. In humans, 48 types of such proteins, including retinoic acid receptors (RARs), vitamin D receptors (VDR), estrogen receptors (ERs), and thyroid hormone receptors (TRs), have been identified. Although the transcriptional activity of nuclear receptors is primarily regulated by binding to specific ligands, post-translational modifications such as phosphorylation also influence it. Recently, we discovered a novel signaling pathway leading from cell-cell adhesion to serine phosphorylation of several nuclear receptors, contributing to both stem cell differentiation and the malignancy of endometrial cancer and breast cancer. This review will introduce the series of studies that led to these discoveries.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"福島医学会","subitem_publisher_language":"ja"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0016-2582","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2436-7826","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AN00216776","subitem_source_identifier_type":"NCID"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"71","bibliographicPageStart":"65","bibliographicVolumeNumber":"73","bibliographic_titles":[{"bibliographic_title":"福島医学雑誌","bibliographic_titleLang":"ja"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5387/fmedj.73.3_65","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2024152476","subitem_relation_type_select":"ICHUSHI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-06-05"}],"displaytype":"detail","filename":"FksmMedJ_73_p65.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2002246/files/FksmMedJ_73_p65.pdf"},"version_id":"75880be0-5632-43fd-a94e-60505328a956"}]},"item_title":"核内受容体の新規調節機構の発見と病理学への展開","item_type_id":"40002","owner":"8","path":["1733474801169"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-05"},"publish_date":"2024-06-05","publish_status":"0","recid":"2002246","relation_version_is_last":true,"title":["核内受容体の新規調節機構の発見と病理学への展開"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2025-01-09T09:09:45.995271+00:00"}