{"created":"2024-12-02T08:36:52.729552+00:00","id":2002003,"links":{},"metadata":{"_buckets":{"deposit":"20a6e51e-2dac-497b-98fa-e61b08bc42f7"},"_deposit":{"created_by":8,"id":"2002003","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2002003"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02002003","sets":["1732778801467:1732778962699:1733128295030"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Cesium suppresses fibroblast proliferation and migration","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Khatun, Ziasmin","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishimura, Natsumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kobayashi, Daisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hazama, Akihiro","creatorNameLang":"en"}]}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-sa/4.0/"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Cesium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fibroblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NIH/3T3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"proliferation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"During wound healing, fibroblasts proliferate from the margin, and migrate into the provisional matrix where they differentiate into myofibroblasts resulting in wound contraction; however, fibroblasts are hyperproliferative during chronic tissue damage. We previously reported that cesium chloride inhibited a human cancer cell proliferation; therefore, cesium is also presumed to suppress fibroblast proliferation. We here investigated the effects of cesium chloride on the proliferation and migration of murine embryotic fibroblast cells, NIH/3T3 cells. Cultured NIH/3T3 cells with 0-10 mM sodium and cesium chloride were counted using trypan blue dye-exclusion method, then cell growth and viability were evaluated. The percentage of wound closure was calculated by scratch assay. The number of the cells was decreased by application of 1-10 mM cesium in a dose-dependent manner, whereas the viability of the cells was unchanged. The treatment with 3-10 mM cesium inhibited the proliferation rate and % of wound closure compared with controls. These results suggested that cesium inhibits the proliferation and migration of fibroblast cells. This study indicates a possible therapeutic role of cesium chloride in the treatment of wound healing and fibrosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"The Fukushima Society of Medical Science","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0016-2590","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2185-4610","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA0065246X","subitem_source_identifier_type":"NCID"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"102","bibliographicPageStart":"97","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Fukushima Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5387/fms.2020-08","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"32624528","subitem_relation_type_select":"PMID"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2021182240","subitem_relation_type_select":"ICHUSHI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-09-03"}],"displaytype":"detail","filename":"FksmJMedSci_66_p97.pdf","filesize":[{"value":"913.9 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2002003/files/FksmJMedSci_66_p97.pdf"},"version_id":"1c422ba7-9ecb-42e7-9abb-10c4f7ed1170"}]},"item_title":"Cesium suppresses fibroblast proliferation and migration","item_type_id":"40002","owner":"8","path":["1733128295030"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-09-03"},"publish_date":"2020-09-03","publish_status":"0","recid":"2002003","relation_version_is_last":true,"title":["Cesium suppresses fibroblast proliferation and migration"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2024-12-02T08:42:22.293850+00:00"}