| アイテムタイプ |
デフォルトアイテムタイプ（フル）fmu(1) |
| 公開日 |
2020-09-03 |
| タイトル |
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|
タイトル |
Cesium suppresses fibroblast proliferation and migration |
|
言語 |
en |
| 作成者 |
Khatun, Ziasmin
Nishimura, Natsumi
Kobayashi, Daisuke
Hazama, Akihiro
|
| 権利情報 |
|
|
権利情報Resource |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
|
権利情報 |
© 2020 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
During wound healing, fibroblasts proliferate from the margin, and migrate into the provisional matrix where they differentiate into myofibroblasts resulting in wound contraction; however, fibroblasts are hyperproliferative during chronic tissue damage. We previously reported that cesium chloride inhibited a human cancer cell proliferation; therefore, cesium is also presumed to suppress fibroblast proliferation. We here investigated the effects of cesium chloride on the proliferation and migration of murine embryotic fibroblast cells, NIH/3T3 cells. Cultured NIH/3T3 cells with 0-10 mM sodium and cesium chloride were counted using trypan blue dye-exclusion method, then cell growth and viability were evaluated. The percentage of wound closure was calculated by scratch assay. The number of the cells was decreased by application of 1-10 mM cesium in a dose-dependent manner, whereas the viability of the cells was unchanged. The treatment with 3-10 mM cesium inhibited the proliferation rate and % of wound closure compared with controls. These results suggested that cesium inhibits the proliferation and migration of fibroblast cells. This study indicates a possible therapeutic role of cesium chloride in the treatment of wound healing and fibrosis. |
| 出版者 |
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|
出版者 |
The Fukushima Society of Medical Science |
| 言語 |
|
|
言語 |
eng |
| 書誌情報 |
en : Fukushima Journal of Medical Science
巻 66,
号 2,
p. 97-102,
発行日 2020
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| 関連情報 |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.5387/fms.2020-08 |
| 関連情報 |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
32624528 |
| 関連情報 |
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|
識別子タイプ |
ICHUSHI |
|
|
関連識別子 |
2021182240 |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0016-2590 |
| 収録物識別子 |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2185-4610 |
| 収録物識別子 |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA0065246X |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Cesium |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
fibroblast |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
NIH/3T3 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
proliferation |
FksmJMedSci_66_p97.pdf (913.9 KB)
