{"created":"2024-11-29T09:04:36.475644+00:00","id":2001794,"links":{},"metadata":{"_buckets":{"deposit":"a6775716-7f11-414c-ac94-4fa137395026"},"_deposit":{"created_by":8,"id":"2001794","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2001794"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02001794","sets":["1732778801467:1732778962699:1732870857483"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Effect of methotrexate on fracture healing","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Satoh, Koichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mark, Hans","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Zachrisson, Peter","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Rydevik, Björn","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Byröd, Gunnar","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kikuchi, Shin-Ichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Konno, Shin-Ichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sekiguchi, Miho","creatorNameLang":"en"}]}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2011 The Fukushima Society of Medical Science","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Fracture healing","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Methotrexate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bone formation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Antirheumatic Agents","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Bone Density","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Bone Density Conservation Agents","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Femur","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Fracture Healing","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Methotrexate","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Osteogenesis","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Rats","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Rats, Sprague-Dawley","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Low doses of methotrexate (MTX) are safe and effective for treating adult and juvenile rheumatoid arthritis. However, because this powerful anti-inflammatory drug might negatively influence the healing of wounds and fractures, MTX administration is often stopped during surgical procedures. The present study assesses the effects of low- and high-dose MTX on early inflammatory processes and bone healing in an experimental model of fracture.Thirty male Sprague-Dawley rats were assigned to low- and high-dose MTX and control groups. A femur was cut using a reciprocating saw and a 2-mm fracture gap was made using a fixator. One or four weeks thereafter, macrophages were immunostained and new bone formation was histomorphometrically measured.Significantly less new bone was formed in the high-dose MTX, than in the control group (p< 0.01), whereas bone formation did not significantly differ between the low-dose MTX and control groups. These results suggested that a low dose of MTX does not affect the early process of endochondral bone formation during fracture healing, whereas a high dose might delay the progress of new periosteal bone formation. Although more macrophages were found in the groups treated with MTX, their impact on surrounding inflammatory processes remains unclear.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"The Fukushima Society of Medical Science","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0016-2590","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2185-4610","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA0065246X","subitem_source_identifier_type":"NCID"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"18","bibliographicPageStart":"11","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Fukushima Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5387/fms.57.11","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"21701078","subitem_relation_type_select":"PMID"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2013092315","subitem_relation_type_select":"ICHUSHI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2011-07-05"}],"displaytype":"detail","filename":"FksmJMedSci_57_p11.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2001794/files/FksmJMedSci_57_p11.pdf"},"version_id":"7c082a15-1fda-4dec-842d-28a02afcc08e"}]},"item_title":"Effect of methotrexate on fracture healing","item_type_id":"40002","owner":"8","path":["1732870857483"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-07-05"},"publish_date":"2011-07-05","publish_status":"0","recid":"2001794","relation_version_is_last":true,"title":["Effect of methotrexate on fracture healing"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2024-11-29T09:13:34.275685+00:00"}