{"created":"2024-11-29T05:20:44.014768+00:00","id":2001722,"links":{},"metadata":{"_buckets":{"deposit":"e90574cd-c165-4f67-bb7a-fa6be6811c76"},"_deposit":{"created_by":8,"id":"2001722","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2001722"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02001722","sets":["1732778801467:1732778962699:1732856458937"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Expression of human glucocorticoid receptor beta of peripheral blood mononuclear cells in patients with severe autoimmune hepatitis","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Rai, Tsuyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Monoe, Kyoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kanno, Yukiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Saito, Hironobu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takahashi, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Irisawa, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohira, Hiromasa","creatorNameLang":"en"}]}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2006 The Fukushima Society of Medical Science","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"glucocorticoid receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"autoimmune hepatitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fulminant hepatic failure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Adult","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Aged","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Female","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Hepatitis, Autoimmune","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Leukocytes, Mononuclear","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Middle Aged","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Receptors, Glucocorticoid","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Reverse Transcriptase Polymerase Chain Reaction","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"We evaluated the expression of human glucocorticoid receptor beta (hGRbeta) in patients with severe autoimmune hepatitis (AIH). The subjects were 27 patients with AIH, including 6 with severe type (prothrombin time [PT] < 40%) and 21 with non-severe type (PT>40%). Total RNA extracted from peripheral blood mononuclear cells (PBMCs) was reversed using reverse transcriptase. The resultant complementary DNA was amplified by reverse transcription polymerase chain reaction (RT-PCR) using specific primers for hGR alpha and beta. The six patients with severe AIH were female; three presented fulminant hepatic failure with hepatic encephalopathy. In all patients with AIH, hGR a was detected. The incidence of hGR beta expression in patients with non-severe type was 42.9% (9/21) ; it was 100% (6/6) in those with severe type. The positive ratio was significantly higher in severe-type patients. These results suggest that hGR beta expression in PBMCs is a novel predictor of AIH severity.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"The Fukushima Society of Medical Science","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0016-2590","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2185-4610","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA0065246X","subitem_source_identifier_type":"NCID"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"70","bibliographicPageStart":"65","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Fukushima Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5387/fms.52.65","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"17427757","subitem_relation_type_select":"PMID"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2007203248","subitem_relation_type_select":"ICHUSHI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2011-05-26"}],"displaytype":"detail","filename":"FksmJMedSci_52_p65.pdf","filesize":[{"value":"673.9 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2001722/files/FksmJMedSci_52_p65.pdf"},"version_id":"e1284561-447e-47ea-b89f-e91a36286b44"}]},"item_title":"Expression of human glucocorticoid receptor beta of peripheral blood mononuclear cells in patients with severe autoimmune hepatitis","item_type_id":"40002","owner":"8","path":["1732856458937"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-05-26"},"publish_date":"2011-05-26","publish_status":"0","recid":"2001722","relation_version_is_last":true,"title":["Expression of human glucocorticoid receptor beta of peripheral blood mononuclear cells in patients with severe autoimmune hepatitis"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2024-11-29T05:33:51.817724+00:00"}