{"created":"2024-11-29T04:54:11.910919+00:00","id":2001702,"links":{},"metadata":{"_buckets":{"deposit":"f9233347-198c-44bf-a1e6-64c5cbaa0931"},"_deposit":{"created_by":8,"id":"2001702","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2001702"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02001702","sets":["1732778801467:1732778962699:1732855259895"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Role of CpG ODN in concanavalin A-induced hepatitis in mice","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Abe, Kazumichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohira, Hiromasa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kobayashi, Hiroko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Rai, Tsuyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Saito, Hironobu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takahashi, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sato, Yukio","creatorNameLang":"en"}]}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2005 The Fukushima Society of Medical Science","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"bacterial DNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"autoimmune hepatitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Adjuvants, Immunologic","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Alanine Transaminase","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Concanavalin A","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Female","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Hepatitis","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Interferon-gamma","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Interleukin-5","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Liver","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Mice","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Mice, Inbred BALB C","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Oligodeoxyribonucleotides","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Tumor Necrosis Factor-alpha","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"OBJECTIVE: To investigate the effects of an intradermal injection of oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs on concanavalin A (Con A)-induced hepatitis, an experimental model of immune-mediated hepatitis. METHODS: Con A was injected intravenously into Balb/c mice. Twelve hours after Con A challenge, blood and liver samples were obtained. CpG ODN was injected intradermally 48 hours before Con A challenge. The extent of liver injury was assessed by determining serum alanine transaminase (ALT) and by liver histology. Serum levels of cytokines, including interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-4 and IL-5, were measured by enzyme-linked immunosorbent assay. RESULTS: Co-administration of Con A and CpG ODN significantly increased serum ALT in mice compared with that in the case of administration of Con A alone (10,268 +/- 4,654 and 1,140 +/- 832 IU/1, respectively, p<0.05). In liver histology, mice treated with CpG ODN and Con A showed more extensive midzonal necrosis than did mice treated with Con A alone. These mice also showed significant increases in serum TNF-alpha and IFN-gamma and decrease in serum IL-5. CONCLUSIONS: The results indicate that CpG ODNs aggravate Con A-induced hepatitis by stimulating the production of T-helper-1 (Th1) cytokines, TNF-alpha and IFN-gamma, suggesting that bacterial DNA that contains unmethylated CpG motifs may contribute to the exacerbation of immune-mediated liver injury.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"The Fukushima Society of Medical Science","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0016-2590","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2185-4610","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA0065246X","subitem_source_identifier_type":"NCID"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"49","bibliographicPageStart":"41","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"Fukushima Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5387/fms.51.41","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"16167672","subitem_relation_type_select":"PMID"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2006278049","subitem_relation_type_select":"ICHUSHI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2011-05-26"}],"displaytype":"detail","filename":"FksmJMedSci_51_p41.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2001702/files/FksmJMedSci_51_p41.pdf"},"version_id":"925ff185-c225-4355-bd7a-9fb941fcdaa2"}]},"item_title":"Role of CpG ODN in concanavalin A-induced hepatitis in mice","item_type_id":"40002","owner":"8","path":["1732855259895"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-05-26"},"publish_date":"2011-05-26","publish_status":"0","recid":"2001702","relation_version_is_last":true,"title":["Role of CpG ODN in concanavalin A-induced hepatitis in mice"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2024-12-11T09:20:12.201776+00:00"}