{"created":"2024-11-21T03:59:45.734476+00:00","id":2000688,"links":{},"metadata":{"_buckets":{"deposit":"fbbd688f-dbbd-4acd-aece-f518660ff52f"},"_deposit":{"created_by":8,"id":"2000688","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2000688"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02000688","sets":["1732153124779:1732153268754:1732153336722"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"ヘムによる翻訳開始因子制御の分子機構 : 総合科学研究会講演録","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"五十嵐, 城太郎","creatorNameLang":"ja"}]}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"ヘムは様々な酵素の活性に必要なだけでなく，ヘム自身が情報伝達分子として働いている。細胞内でのヘムの濃度は，ヘムセンサータンパク質によって厳密に制御されている。ヘム調節インヒビターHRIはヘムセンサータンパク質の1つであり，赤血球前駆体において，ヘモグロビン合成の調節を行っている。即ち，ヘムの濃度が減少するとHRI は翻訳開始因子をリン酸化することで，グロビンタンパク質の合成を抑制する。HRIの機能調節について，分子レベルでの機構を解明するために，HRIにおけるヘムの結合性と自己リン酸化反応についてまとめた。さらに，臨床医学と関連した，HRIのがん組織における働きと，治療を目的とした創薬についても述べる。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"第21回総合科学研究会(2011年9月27日)","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"福島県立医科大学総合科学教育研究センター","subitem_publisher_language":"ja"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"2187-3321","subitem_source_identifier_type":"EISSN"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-11-27","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"21","bibliographicPageStart":"16","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"福島県立医科大学総合科学教育研究センター紀要","bibliographic_titleLang":"ja"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-11-14"}],"displaytype":"detail","filename":"IcshKiyo_1-p16.pdf","filesize":[{"value":"704.4 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2000688/files/IcshKiyo_1-p16.pdf"},"version_id":"0f26d00e-0858-46f4-bc3d-020b831cf8eb"}]},"item_title":"ヘムによる翻訳開始因子制御の分子機構 : 総合科学研究会講演録","item_type_id":"40002","owner":"8","path":["1732153336722"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-11-14"},"publish_date":"2017-11-14","publish_status":"0","recid":"2000688","relation_version_is_last":true,"title":["ヘムによる翻訳開始因子制御の分子機構 : 総合科学研究会講演録"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2024-12-20T03:30:01.706104+00:00"}