{"created":"2024-11-12T05:07:18.121923+00:00","id":2000048,"links":{},"metadata":{"_buckets":{"deposit":"18c7ad0b-3f3b-4179-ae0c-2ef8d8967986"},"_deposit":{"created_by":8,"id":"2000048","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2000048"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02000048","sets":["1623632832836:1730783669761"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Prenylated Quinolinecarboxylic Acid Derivative Prevents Neuronal Cell Death Through Inhibition of MKK4","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ogura, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kikuchi, Haruhisa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shakespear, Norshalena","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suzuki, Toshiyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamaki, Junko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Homma, Miwako K","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Oshima, Yoshiteru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Homma, Yoshimi","creatorNameLang":"en"}]}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Neuronal cell death","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neurodegeneration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MAPK","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neurotoxin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"small molecule","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Carboxylic Acids","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Cell Death","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Cell Line","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"MAP Kinase Kinase 4","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Mice","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Mice, Inbred C57BL","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Neurons","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Neuroprotective Agents","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Prenylation","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Quinolines","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The development of neuroprotective agents is necessary for the treatment of neurodegenerative diseases. Here, we report PQA-11, a prenylated quinolinecarboxylic acid (PQA) derivative, as a potent neuroprotectant. PQA-11 inhibits glutamate-induced cell death and caspase-3 activation in hippocampal cultures, as well as inhibits N-Methyl-4-phenylpyridinium iodide- and amyloid β1-42-induced cell death in SH-SY5Y cells. PQA-11 also suppresses mitogen-activated protein kinase kinase 4 (MKK4) and c-jun N-terminal kinase (JNK) signaling activated by these neurotoxins. Quartz crystal microbalance analysis and in vitro kinase assay reveal that PQA-11 interacts with MKK4, and inhibits its sphingosine-induced activation. The administration of PQA-11 by intraperitoneal injection alleviates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of nigrostriatal dopaminergic neurons in mice. These results suggest that PQA-11 is a unique MKK4 inhibitor with potent neuroprotective effects in vitro and in vivo. PQA-11 may be a valuable lead for the development of novel neuroprotectants.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0006-2952","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"1873-2968","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA00564486","subitem_source_identifier_type":"NCID"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-04","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"122","bibliographicPageStart":"109","bibliographicVolumeNumber":"162","bibliographic_titles":[{"bibliographic_title":"Biochemical pharmacology","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bcp.2018.10.008","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"30316820","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-04-01"}],"displaytype":"detail","filename":"BiochemPharmacol_162_p109.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2000048/files/BiochemPharmacol_162_p109.pdf"},"version_id":"d98dbd28-0542-4a93-8d77-309cb40f3366"}]},"item_title":"Prenylated Quinolinecarboxylic Acid Derivative Prevents Neuronal Cell Death Through Inhibition of MKK4","item_type_id":"40002","owner":"8","path":["1730783669761"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-04-01"},"publish_date":"2020-04-01","publish_status":"0","recid":"2000048","relation_version_is_last":true,"title":["Prenylated Quinolinecarboxylic Acid Derivative Prevents Neuronal Cell Death Through Inhibition of MKK4"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2025-01-07T06:27:09.296476+00:00"}