{"created":"2024-11-12T05:06:35.764612+00:00","id":2000022,"links":{},"metadata":{"_buckets":{"deposit":"de912c26-dcbf-4e6b-a257-2369cd339749"},"_deposit":{"created_by":8,"id":"2000022","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2000022"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02000022","sets":["1623632832836:1730783669761"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Clinical features of liver dysfunction in collagen diseases","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahashi, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Abe, Kazumichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yokokawa, Junko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iwadate, Haruyo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kobayashi, Hiroko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Watanabe, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Irisawa, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohira, Hiromasa","creatorNameLang":"en"}]}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Author posting. © The Japan Society of Hepatology 2010. This is the author’s version of the work. It is posted here by permission of Hepatology Research. 40(11):1092-1097. http://dx.doi.org/10.1111/j.1872-034X.2010.00707.x","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"collagen disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"liver dysfunction","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Aim:  Liver dysfunction is not rare in patients with collagen disease. We sought to elucidate the clinical features of liver dysfunction in the presence of collagen disease. Methods:  We analyzed the frequency and causes of liver dysfunction in 607 patients (rheumatoid arthritis [RA], n = 220; systemic lupus erythematosus [SLE], n = 164; systemic sclerosis [SSc], n = 47; Sjögren's syndrome [SjS], n = 44; Behçet's disease, n = 43; polymyositis/dermatomyositis [PM/DM], n = 27; vasculitis syndrome, n = 25; mixed connective tissue disease [MCTD], n = 21; and adult-onset Still's disease [AOSD], n = 16). Results:  Liver dysfunction was observed in 238 (39.2%) of 607 patients showing collagen disease. Patients with AOSD (81.3%), PM/DM (51.9%) and vasculitis syndrome (48.0%) frequently displayed liver dysfunction. Liver dysfunction in collagen diseases results from many causes; drug-induced liver injury (26.1%), fatty liver (7.6%), viral hepatitis (1.3%), autoimmune hepatitis (4.2%), primary biliary cirrhosis (15.9%) and the collagen disease itself (15.5%). Conversely, primary biliary cirrhosis was a leading cause in SSc (76.1%) and SjS (70.0%). Liver dysfunction in collagen disease tended to be mild. In addition, alanine aminotransferase levels correlated positively with ferritin levels in AOSD (R = 0.708, P < 0.05). Moreover, alkaline phosphatase levels correlated positively with C reactive protein levels in vasculitis syndrome (R = 0.833, P < 0.05). Conclusion:  Liver dysfunction in the presence of collagen disease has various causes, and dysfunction associated with collagen disease reflects the activity of the collagen disease itself.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Wiley-Blackwell","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1386-6346","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"1872-034X","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA11140867","subitem_source_identifier_type":"NCID"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1097","bibliographicPageStart":"1092","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Hepatology Research","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/j.1872-034X.2010.00707.x","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"20880057","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2013-08-02"}],"displaytype":"detail","filename":"HepatolRes_40_p1092.pdf","filesize":[{"value":"378.9 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2000022/files/HepatolRes_40_p1092.pdf"},"version_id":"267d2453-1825-4d0f-8d98-3a9ec9cd6913"}]},"item_title":"Clinical features of liver dysfunction in collagen diseases","item_type_id":"40002","owner":"8","path":["1730783669761"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-02"},"publish_date":"2013-08-02","publish_status":"0","recid":"2000022","relation_version_is_last":true,"title":["Clinical features of liver dysfunction in collagen diseases"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2025-01-07T06:26:53.597195+00:00"}