{"created":"2024-11-12T05:06:32.083041+00:00","id":2000019,"links":{},"metadata":{"_buckets":{"deposit":"072820a0-69a3-4b40-a163-2f40bb1ca120"},"_deposit":{"created_by":8,"id":"2000019","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2000019"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02000019","sets":["1623632832836:1730783669761"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Effects of a high-sodium diet on renal tubule Ca2+ transporter and claudin expression in Wistar-Kyoto rats","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yatabe, Midori Sasaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yatabe, Junichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takano, Kozue","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Murakami, Yuta","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sakuta, Rina","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Abe, Sadahiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sanada, Hironobu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kimura, Junko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Watanabe, Tsuyoshi","creatorNameLang":"en"}]}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2012 Yatabe et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by/2.0"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Calcium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sodium chloride","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Distal tubule","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Na+/Ca2+ exchanger","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ca2+ channel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Claudins","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Background: Urinary Ca^{2+} excretion increases with dietary NaCl. NaCl-induced calciuria may be associated with hypertension, urinary stone formation and osteoporosis, but its mechanism and long-term effects are not fully understood. This study examined alterations in the expressions of renal Ca^{2+} transporters, channels and claudins upon salt loading to better understand the mechanism of salt-induced urinary Ca^{2+} loss. Methods: Eight-week old Wistar-Kyoto rats were fed either 0.3% or 8% NaCl diet for 8 weeks. Renal cortical expressions of Na+/Ca2+ exchanger 1 (NCX1), Ca^{2+} pump (PCMA1b), Ca^{2+} channel (TRPV5), calbindin-D28k, and claudins (CLDN-2, -7, -8, -16 and −19) were analyzed by quantitative PCR, western blot and/or immunohistochemistry. Results: Fractional excretion of Ca^{2+} increased 6.0 fold with high-salt diet. Renal cortical claudin-2 protein decreased by approximately 20% with decreased immunological staining on tissue sections. Claudin-16 and −19 expressions were not altered. Renal cortical TRPV5, calbindin-D28k and NCX1 expressions increased 1.6, 1.5 and 1.2 fold, respectively. Conclusions: Chronic high-salt diet decreased claudin-2 protein and increased renal TRPV5, calbindin-D28k, and NCX1. Salt loading is known to reduce the proximal tubular reabsorption of both Na+ and Ca^{2+}. The reduction in claudin-2 protein expression may be partly responsible for the reduced Ca^{2+} reabsorption in this segment. The concerted upregulation of more distal Ca^{2+}-transporting molecules may be a physiological response to curtail the loss of Ca^{2+}, although the magnitude of compensation does not seem adequate to bring the urinary Ca^{2+} excretion down to that of the normal-diet group.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd.","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1471-2369","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA12035314","subitem_source_identifier_type":"NCID"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"160","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"BMC nephrology","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/1471-2369-13-160","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"23199000","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2013-07-01"}],"displaytype":"detail","filename":"1471-2369-13-160.pdf","filesize":[{"value":"944.0 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2000019/files/1471-2369-13-160.pdf"},"version_id":"06da8dcc-b2a4-4d03-9e21-d9a0e51d4c61"}]},"item_title":"Effects of a high-sodium diet on renal tubule Ca2+ transporter and claudin expression in Wistar-Kyoto rats","item_type_id":"40002","owner":"8","path":["1730783669761"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-07-01"},"publish_date":"2013-07-01","publish_status":"0","recid":"2000019","relation_version_is_last":true,"title":["Effects of a high-sodium diet on renal tubule Ca2+ transporter and claudin expression in Wistar-Kyoto rats"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2025-01-07T06:26:52.612150+00:00"}