{"created":"2024-11-12T05:06:25.081118+00:00","id":2000015,"links":{},"metadata":{"_buckets":{"deposit":"fa121ce8-b70b-4100-ba51-678ec68a073e"},"_deposit":{"created_by":8,"id":"2000015","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2000015"},"status":"published"},"_oai":{"id":"oai:fmu.repo.nii.ac.jp:02000015","sets":["1623632832836:1730783669761"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Role of diacylglycerol kinase in cellular regulatory processes: A new regulator for cardiomyocyte hypertrophy","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takeishi, Yasuchika","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Goto, Kaoru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kubota, Isao","creatorNameLang":"en"}]}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright © 2007 Elsevier Inc. All rights reserved.","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"heart failure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"protein kinase C","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Diacylglycerol Kinase","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Drug Delivery Systems","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Gene Expression Regulation, Enzymologic","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Hypertrophy","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Isoenzymes","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Mice","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Myocardial Infarction","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Myocytes, Cardiac","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Rats","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Signal Transduction","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"},{"subitem_subject":"Ventricular Remodeling","subitem_subject_language":"en","subitem_subject_scheme":"MeSH"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Diacylglycerol kinase (DGK) phosphorylates and converts diacylglycerol (DAG) to phosphatidic acid. DGK regulates cellular DAG levels and attenuates DAG signaling. The ten mammalian DGK isoforms have been identified to date. In cardiac myocytes, DGKα, ε, and ζ are expressed, and DGKζ is the predominant isoform. DGKζ inhibits protein kinase C activation and subsequent hypertrophic programs in response to endothelin-1 in neonatal rat cardiomyocytes. DGKζ blocks cardiac hypertrophy induced by G protein-coupled receptor agonists and pressure-overload in vivo. DGKζ attenuates ventricular remodeling and improves survival after myocardial infarction. These data provide a novel insight for subcellular mechanisms of cardiac hypertrophy and heart failure, and DGKζ may be a new therapeutic target to prevent cardiac hypertrophy and progression to heart failure.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc.","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0163-7258","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"1879-016X ","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA00361944","subitem_source_identifier_type":"NCID"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"359","bibliographicPageStart":"352","bibliographicVolumeNumber":"115","bibliographic_titles":[{"bibliographic_title":"Pharmacology & Therapeutics","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.pharmthera.2007.04.010","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"17659347","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2010-06-08"}],"displaytype":"detail","filename":"PharmacolTher_115_p352.pdf","filesize":[{"value":"364.1 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://fmu.repo.nii.ac.jp/record/2000015/files/PharmacolTher_115_p352.pdf"},"version_id":"04568155-71ef-4fcd-8e9b-3fbda5340b72"}]},"item_title":"Role of diacylglycerol kinase in cellular regulatory processes: A new regulator for cardiomyocyte hypertrophy","item_type_id":"40002","owner":"8","path":["1730783669761"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-06-08"},"publish_date":"2010-06-08","publish_status":"0","recid":"2000015","relation_version_is_last":true,"title":["Role of diacylglycerol kinase in cellular regulatory processes: A new regulator for cardiomyocyte hypertrophy"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2025-01-07T06:27:03.247868+00:00"}